Daily amylin replacement reverses hepatic glycogen depletion in insulin-treated streptozotocin diabetic rats.

Andrew A. Young; L B Crocker; D Wolfe-Lopez; Garth Cooper

doi:10.1016/0014-5793(91)80051-4

Daily amylin replacement reverses hepatic glycogen depletion in insulin-treated streptozotocin diabetic rats.

Andrew A. Young, L B Crocker, D Wolfe-Lopez, Garth Cooper

Division of Cardiovascular Sciences (L5)

Amylin Pharmaceuticals

Research output: Contribution to journal › Article › peer-review

Abstract

In streptozotocin-diabetic rats treated with insulin replacement, liver glycogen is some 35% depleted. Five consecutive daily subcutaneous injections with amylin dose-dependently restored liver glycogen to normal levels. Significant increases over insulin-only therapy occurred with amylin doses of 10, 30 and 100 micrograms/day, representing amylin: insulin ratios of 0.22, 0.75 and 2.79.

Original language	English
Pages (from-to)	203-205
Journal	FEBS Letters
Volume	287
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(91)80051-4
Publication status	Published - 5 Aug 1991

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10.1016/0014-5793(91)80051-4

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title = "Daily amylin replacement reverses hepatic glycogen depletion in insulin-treated streptozotocin diabetic rats.",

abstract = "In streptozotocin-diabetic rats treated with insulin replacement, liver glycogen is some 35% depleted. Five consecutive daily subcutaneous injections with amylin dose-dependently restored liver glycogen to normal levels. Significant increases over insulin-only therapy occurred with amylin doses of 10, 30 and 100 micrograms/day, representing amylin: insulin ratios of 0.22, 0.75 and 2.79.",

author = "Young, {Andrew A.} and Crocker, {L B} and D Wolfe-Lopez and Garth Cooper",

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AU - Young, Andrew A.

AU - Crocker, L B

AU - Wolfe-Lopez, D

AU - Cooper, Garth

PY - 1991/8/5

Y1 - 1991/8/5

N2 - In streptozotocin-diabetic rats treated with insulin replacement, liver glycogen is some 35% depleted. Five consecutive daily subcutaneous injections with amylin dose-dependently restored liver glycogen to normal levels. Significant increases over insulin-only therapy occurred with amylin doses of 10, 30 and 100 micrograms/day, representing amylin: insulin ratios of 0.22, 0.75 and 2.79.

AB - In streptozotocin-diabetic rats treated with insulin replacement, liver glycogen is some 35% depleted. Five consecutive daily subcutaneous injections with amylin dose-dependently restored liver glycogen to normal levels. Significant increases over insulin-only therapy occurred with amylin doses of 10, 30 and 100 micrograms/day, representing amylin: insulin ratios of 0.22, 0.75 and 2.79.

U2 - 10.1016/0014-5793(91)80051-4

DO - 10.1016/0014-5793(91)80051-4

M3 - Article

C2 - 1879531

SN - 0014-5793

VL - 287

SP - 203

EP - 205

JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

Daily amylin replacement reverses hepatic glycogen depletion in insulin-treated streptozotocin diabetic rats.

Abstract

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