Daptomycin: Pharmacology and clinical use

Christos Kosmidis, Donald P. Levine

Research output: Contribution to journalReview articlepeer-review


Importance of the field: Infections caused by Gram-positive organisms have increased in frequency and severity. Daptomycin offers a therapeutic option in an era of increasing resistance. Areas covered in this review: Literature from 1986 to present was reviewed for pharmacological, preclinical and clinical studies on daptomycin. What the reader will gain: The pharmacological properties, resistance mechanisms and clinical applications of daptomycin are discussed. Recommendations are offered on the use of this agent for the treatment of resistant Gram-positive infections. Take home message: Daptomycin is a reliable agent for the treatment of Gram-positive infections. It has been shown to be effective in bacteremia and endocarditis, as well as in soft-tissue infections caused by Gram-positive organisms. Its role in the treatment of bone and joint infections is not well-defined. Resistance is currently uncommon in clinical isolates. However, emergence of resistance during therapy is a concern. This may be prevented by use of higher doses.

Original languageEnglish
Pages (from-to)615-625
Number of pages11
JournalExpert opinion on pharmacotherapy
Issue number4
Publication statusPublished - 1 Mar 2010


  • Daptomycin
  • Gram-positive infections
  • Pharmacology
  • Resistance


Dive into the research topics of 'Daptomycin: Pharmacology and clinical use'. Together they form a unique fingerprint.

Cite this