Data on the histological and immune cell response in the popliteal lymph node in mice following exposure to metal particles and ions

Bethany Winans, Brooke E. Tvermoes, Kenneth M. Unice, Michael Kovochich, Ernest S. Fung, Whitney V. Christian, Ellen Donovan, Brent L. Finley, Ian Kimber, Dennis J. Paustenbach

Research output: Contribution to journalArticlepeer-review

Abstract

Hip implants containing cobalt–chromium (CoCr) have been used for over 80 years. In patients with metal-on-metal (MoM) hip implants, it has been suggested that wear debris particles may contribute to metal sensitization in some individuals, leading to adverse reactions. This article presents data from a study in which the popliteal lymph node assay (PLNA) was used to assess immune responses in mice treated with chromium-oxide (Cr2O3) particles, metal salts (CoCl2, CrCl3, and NiCl2) or Cr2O3 particles with metal salts (“A preliminary evaluation of immune stimulation following exposure to metal particles and ions using the mouse popliteal lymph node assay” (B.E. Tvermoes, K.M. Unice, B. Winans, M. Kovochich, E.S. Fung, W.V. Christian, E. Donovan, B.L. Finley, B.L. Kimber, I. Kimber, D.J. Paustenbach, 2016) [1]). Data are presented on (1) the chemical characterization of TiO2 particles (used as a particle control), (2) clinical observations in mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts, (3) PLN weight and weight index (WI) in mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts, (4) histological changes in PLNs of mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts, (5) percentages of immune cells in the PLNs of mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts, and (6) percentages of proliferating cells in the PLNs of mice treated with Cr2O3 particles, metal salts or Cr2O3 particles with metal salts.

Original languageEnglish
Pages (from-to)388-397
Number of pages10
JournalData in Brief
Volume9
Early online date27 Aug 2016
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • Hypersensitivity
  • Immune stimulation
  • Lymph node cell activation
  • Metal-on-metal implants
  • Metals
  • Particles
  • Popliteal lymph node assay

Research Beacons, Institutes and Platforms

  • Manchester Institute for Collaborative Research on Ageing

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