Deaminative Strategy for the Visible-Light-Mediated Generation of Alkyl Radicals

Felix J. R. Klauck, Michael J. James, Frank Glorius

Research output: Contribution to journalArticlepeer-review

Abstract

A deaminative strategy for the visible-light-mediated generation of alkyl radicals from redox-activated primary amine precursors is described. Abundant and inexpensive primary amine feedstocks, including amino acids, were converted in a single step into redox-active pyridinium salts and subsequently into alkyl radicals by reaction with an excited-state photocatalyst. The broad synthetic potential of this protocol was demonstrated by the alkylation of a number of heteroarenes under mild conditions.
Original languageEnglish
Pages (from-to)12336-12339
Number of pages4
JournalAngewandte Chemie International Edition
Volume56
Issue number40
DOIs
Publication statusPublished - 31 Jul 2017

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