Decarboxylative C-H cross-coupling of azoles

Fengzhi Zhang, Michael F. Greaney

    Research output: Contribution to journalArticlepeer-review


    (Figure Presented) Côte d'Azole: The title reaction demon-strates the use of diverse oxazoles 2 as suitable substrates in cross-coupling reactions with azole-5-carboxylic acids 1 under palladium catalysis in the presence of copper carbonate. The reaction is successful for the synthesis of a range of bis(azole)s, and has been applied to the convergent synthesis of challenging poly azoles (dcpe = bis(dicyclohexylphosphi-no)ethane, DMSO = dimethyl sulfoxide, M.S. = molecular sieves). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)2768-2771
    Number of pages3
    JournalAngewandte Chemie - International Edition
    Issue number15
    Publication statusPublished - 1 Apr 2010


    • C-h activation
    • Catalysis
    • Cross-coupling
    • Heterocycles
    • Palladium


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