Decarboxylative C-H cross-coupling of azoles

Fengzhi Zhang; Michael F. Greaney

doi:10.1002/anie.200906921

Decarboxylative C-H cross-coupling of azoles

Fengzhi Zhang
, Michael F. Greaney

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure Presented) Côte d'Azole: The title reaction demon-strates the use of diverse oxazoles 2 as suitable substrates in cross-coupling reactions with azole-5-carboxylic acids 1 under palladium catalysis in the presence of copper carbonate. The reaction is successful for the synthesis of a range of bis(azole)s, and has been applied to the convergent synthesis of challenging poly azoles (dcpe = bis(dicyclohexylphosphi-no)ethane, DMSO = dimethyl sulfoxide, M.S. = molecular sieves). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

Original language	English
Pages (from-to)	2768-2771
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	15
DOIs	https://doi.org/10.1002/anie.200906921
Publication status	Published - 1 Apr 2010

Keywords

C-h activation
Catalysis
Cross-coupling
Heterocycles
Palladium

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title = "Decarboxylative C-H cross-coupling of azoles",

abstract = "(Figure Presented) C{\^o}te d'Azole: The title reaction demon-strates the use of diverse oxazoles 2 as suitable substrates in cross-coupling reactions with azole-5-carboxylic acids 1 under palladium catalysis in the presence of copper carbonate. The reaction is successful for the synthesis of a range of bis(azole)s, and has been applied to the convergent synthesis of challenging poly azoles (dcpe = bis(dicyclohexylphosphi-no)ethane, DMSO = dimethyl sulfoxide, M.S. = molecular sieves). {\textcopyright} 2010 Wiley-VCH Verlag GmbH \& Co. KGaA.",

keywords = "C-h activation, Catalysis, Cross-coupling, Heterocycles, Palladium",

author = "Fengzhi Zhang and Greaney, \{Michael F.\}",

note = "CAPLUS AN 2010:415821(Journal)",

year = "2010",

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language = "English",

volume = "49",

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T1 - Decarboxylative C-H cross-coupling of azoles

AU - Zhang, Fengzhi

AU - Greaney, Michael F.

N1 - CAPLUS AN 2010:415821(Journal)

PY - 2010/4/1

Y1 - 2010/4/1

N2 - (Figure Presented) Côte d'Azole: The title reaction demon-strates the use of diverse oxazoles 2 as suitable substrates in cross-coupling reactions with azole-5-carboxylic acids 1 under palladium catalysis in the presence of copper carbonate. The reaction is successful for the synthesis of a range of bis(azole)s, and has been applied to the convergent synthesis of challenging poly azoles (dcpe = bis(dicyclohexylphosphi-no)ethane, DMSO = dimethyl sulfoxide, M.S. = molecular sieves). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

AB - (Figure Presented) Côte d'Azole: The title reaction demon-strates the use of diverse oxazoles 2 as suitable substrates in cross-coupling reactions with azole-5-carboxylic acids 1 under palladium catalysis in the presence of copper carbonate. The reaction is successful for the synthesis of a range of bis(azole)s, and has been applied to the convergent synthesis of challenging poly azoles (dcpe = bis(dicyclohexylphosphi-no)ethane, DMSO = dimethyl sulfoxide, M.S. = molecular sieves). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

KW - C-h activation

KW - Catalysis

KW - Cross-coupling

KW - Heterocycles

KW - Palladium

U2 - 10.1002/anie.200906921

DO - 10.1002/anie.200906921

M3 - Article

SN - 1433-7851

VL - 49

SP - 2768

EP - 2771

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 15

ER -

Decarboxylative C-H cross-coupling of azoles

Abstract

Keywords

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