Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence

S. T. Cole; R. Brosch; J. Parkhill; T. Garnier; C. Churcher; D. Harris; S. V. Gordon; K. Eiglmeier; S. Gas; C. E. Barry; F. Tekaia; K. Badcock; D. Basham; D. Brown; T. Chillingworth; R. Connor; R. Davies; K. Devlin; T. Feltwell; S. Gentles; N. Hamlin; S. Holroyd; T. Hornsby; K. Jagels; A. Krogh; J. McLean; S. Moule; L. Murphy; K. Oliver; J. Osborne; M. A. Quail; M. A. Rajandream; J. Rogers; S. Rutter; K. Seeger; J. Skelton; R. Squares; S. Squares; J. E. Sulston; K. Taylor; S. Whitehead; B. G. Barrell

doi:10.1038/31159

Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence

S. T. Cole, R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, S. V. Gordon, K. Eiglmeier, S. Gas, C. E. Barry, F. Tekaia, K. Badcock, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. Davies, K. Devlin, T. Feltwell, S. GentlesN. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, A. Krogh, J. McLean, S. Moule, L. Murphy, K. Oliver, J. Osborne, M. A. Quail, M. A. Rajandream, J. Rogers, S. Rutter, K. Seeger, J. Skelton, R. Squares, S. Squares, J. E. Sulston, K. Taylor, S. Whitehead, B. G. Barrell

Research output: Contribution to journal › Article › peer-review

Abstract

Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to Improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of it coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

Original language	English
Pages (from-to)	537-544
Number of pages	7
Journal	Nature
Volume	393
Issue number	6685
DOIs	https://doi.org/10.1038/31159
Publication status	Published - 11 Jun 1998

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/31159

Cite this

Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., ... Barrell, B. G. (1998). Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence. Nature, 393(6685), 537-544. https://doi.org/10.1038/31159

@article{73893b4d96d542a7a60a91c441c569ca,

title = "Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence",

abstract = "Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to Improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of it coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.",

author = "Cole, {S. T.} and R. Brosch and J. Parkhill and T. Garnier and C. Churcher and D. Harris and Gordon, {S. V.} and K. Eiglmeier and S. Gas and Barry, {C. E.} and F. Tekaia and K. Badcock and D. Basham and D. Brown and T. Chillingworth and R. Connor and R. Davies and K. Devlin and T. Feltwell and S. Gentles and N. Hamlin and S. Holroyd and T. Hornsby and K. Jagels and A. Krogh and J. McLean and S. Moule and L. Murphy and K. Oliver and J. Osborne and Quail, {M. A.} and Rajandream, {M. A.} and J. Rogers and S. Rutter and K. Seeger and J. Skelton and R. Squares and S. Squares and Sulston, {J. E.} and K. Taylor and S. Whitehead and Barrell, {B. G.}",

note = "Z01 AI000783-11, AI, NIAID NIH HHS, United States",

year = "1998",

month = jun,

day = "11",

doi = "10.1038/31159",

language = "English",

volume = "393",

pages = "537--544",

journal = "Nature",

issn = "0028-0836",

publisher = "Springer Nature",

number = "6685",

}

Cole, ST, Brosch, R, Parkhill, J, Garnier, T, Churcher, C, Harris, D, Gordon, SV, Eiglmeier, K, Gas, S, Barry, CE, Tekaia, F, Badcock, K, Basham, D, Brown, D, Chillingworth, T, Connor, R, Davies, R, Devlin, K, Feltwell, T, Gentles, S, Hamlin, N, Holroyd, S, Hornsby, T, Jagels, K, Krogh, A, McLean, J, Moule, S, Murphy, L, Oliver, K, Osborne, J, Quail, MA, Rajandream, MA, Rogers, J, Rutter, S, Seeger, K, Skelton, J, Squares, R, Squares, S, Sulston, JE, Taylor, K, Whitehead, S & Barrell, BG 1998, 'Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence', Nature, vol. 393, no. 6685, pp. 537-544. https://doi.org/10.1038/31159

TY - JOUR

T1 - Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence

AU - Cole, S. T.

AU - Brosch, R.

AU - Parkhill, J.

AU - Garnier, T.

AU - Churcher, C.

AU - Harris, D.

AU - Gordon, S. V.

AU - Eiglmeier, K.

AU - Gas, S.

AU - Barry, C. E.

AU - Tekaia, F.

AU - Badcock, K.

AU - Basham, D.

AU - Brown, D.

AU - Chillingworth, T.

AU - Connor, R.

AU - Davies, R.

AU - Devlin, K.

AU - Feltwell, T.

AU - Gentles, S.

AU - Hamlin, N.

AU - Holroyd, S.

AU - Hornsby, T.

AU - Jagels, K.

AU - Krogh, A.

AU - McLean, J.

AU - Moule, S.

AU - Murphy, L.

AU - Oliver, K.

AU - Osborne, J.

AU - Quail, M. A.

AU - Rajandream, M. A.

AU - Rogers, J.

AU - Rutter, S.

AU - Seeger, K.

AU - Skelton, J.

AU - Squares, R.

AU - Squares, S.

AU - Sulston, J. E.

AU - Taylor, K.

AU - Whitehead, S.

AU - Barrell, B. G.

N1 - Z01 AI000783-11, AI, NIAID NIH HHS, United States

PY - 1998/6/11

Y1 - 1998/6/11

N2 - Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to Improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of it coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

AB - Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to Improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of it coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.

U2 - 10.1038/31159

DO - 10.1038/31159

M3 - Article

C2 - 9634230

SN - 0028-0836

VL - 393

SP - 537

EP - 544

JO - Nature

JF - Nature

IS - 6685

ER -

Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this