Decline of astrocyte Ca2+ signalling in Alzheimer's disease: STIM1 to the rescue!

Alexei Verkhratsky; Alexey Semyanov

doi:10.1016/j.ceca.2023.102756

Decline of astrocyte Ca²⁺ signalling in Alzheimer's disease: STIM1 to the rescue!

Alexei Verkhratsky^*, Alexey Semyanov

^*Corresponding author for this work

Division of Neuroscience

Research output: Contribution to journal › Commentary/debate › peer-review

Abstract

Lia et al. [1] discovered the critical role of STIM1 ER Ca²⁺ sensor in the functional decline of astrocytes in the AD-like pathology in PS2APP mice. Profound downregulation of STIM1 expression in astrocytes in the disease results in the decreased ER Ca²⁺ content and severely impaired evoked as well as spontaneous astrocytic Ca²⁺ signalling. Aberrant astrocytic Ca²⁺ signalling translated into impaired synaptic plasticity and memory. Astrocyte-specific overexpression of STIM1 restored Ca²⁺ excitability and rectified synaptic and memory deficits.

Original language	English
Article number	102756
Journal	Cell calcium
Volume	113
Early online date	10 May 2023
DOIs	https://doi.org/10.1016/j.ceca.2023.102756
Publication status	Published - 1 Jul 2023

Keywords

Alzheimer Disease/metabolism
Animals
Astrocytes/metabolism
Calcium Signaling/physiology
Mice
Neuronal Plasticity/physiology

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10.1016/j.ceca.2023.102756

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title = "Decline of astrocyte Ca2+ signalling in Alzheimer's disease: STIM1 to the rescue!",

abstract = "Lia et al. [1] discovered the critical role of STIM1 ER Ca2+ sensor in the functional decline of astrocytes in the AD-like pathology in PS2APP mice. Profound downregulation of STIM1 expression in astrocytes in the disease results in the decreased ER Ca2+ content and severely impaired evoked as well as spontaneous astrocytic Ca2+ signalling. Aberrant astrocytic Ca2+ signalling translated into impaired synaptic plasticity and memory. Astrocyte-specific overexpression of STIM1 restored Ca2+ excitability and rectified synaptic and memory deficits.",

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AU - Verkhratsky, Alexei

AU - Semyanov, Alexey

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Y1 - 2023/7/1

N2 - Lia et al. [1] discovered the critical role of STIM1 ER Ca2+ sensor in the functional decline of astrocytes in the AD-like pathology in PS2APP mice. Profound downregulation of STIM1 expression in astrocytes in the disease results in the decreased ER Ca2+ content and severely impaired evoked as well as spontaneous astrocytic Ca2+ signalling. Aberrant astrocytic Ca2+ signalling translated into impaired synaptic plasticity and memory. Astrocyte-specific overexpression of STIM1 restored Ca2+ excitability and rectified synaptic and memory deficits.

AB - Lia et al. [1] discovered the critical role of STIM1 ER Ca2+ sensor in the functional decline of astrocytes in the AD-like pathology in PS2APP mice. Profound downregulation of STIM1 expression in astrocytes in the disease results in the decreased ER Ca2+ content and severely impaired evoked as well as spontaneous astrocytic Ca2+ signalling. Aberrant astrocytic Ca2+ signalling translated into impaired synaptic plasticity and memory. Astrocyte-specific overexpression of STIM1 restored Ca2+ excitability and rectified synaptic and memory deficits.

KW - Alzheimer Disease/metabolism

KW - Animals

KW - Astrocytes/metabolism

KW - Calcium Signaling/physiology

KW - Mice

KW - Neuronal Plasticity/physiology

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JO - Cell calcium

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Decline of astrocyte Ca²⁺ signalling in Alzheimer's disease: STIM1 to the rescue!

Abstract

Keywords

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