Decline of astrocyte Ca2+ signalling in Alzheimer's disease: STIM1 to the rescue!

Alexei Verkhratsky, Alexey Semyanov

Research output: Contribution to journalComment/debatepeer-review

Abstract

Lia et al. [1] discovered the critical role of STIM1 ER Ca2+ sensor in the functional decline of astrocytes in the AD-like pathology in PS2APP mice. Profound downregulation of STIM1 expression in astrocytes in the disease results in the decreased ER Ca2+ content and severely impaired evoked as well as spontaneous astrocytic Ca2+ signalling. Aberrant astrocytic Ca2+ signalling translated into impaired synaptic plasticity and memory. Astrocyte-specific overexpression of STIM1 restored Ca2+ excitability and rectified synaptic and memory deficits.

Original languageEnglish
Article number102756
JournalCell calcium
Volume113
Early online date10 May 2023
DOIs
Publication statusPublished - 1 Jul 2023

Keywords

  • Alzheimer Disease/metabolism
  • Animals
  • Astrocytes/metabolism
  • Calcium Signaling/physiology
  • Mice
  • Neuronal Plasticity/physiology

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