Definitions of histocompatibility typing terms

Helen Heslop, Eduardo Nunes, Marcelo Fernandez-Vina, Cynthia Taves, Dawn R Wagenknecht, A Bradley Eisenbrey, Gottfried Fischer, Kay Poulton, Kara Wacker, Carolyn Katovich Hurley, Harriet Noreen, Nicoletta Sacchi

Research output: Contribution to journalArticlepeer-review


Histocompatibility testing for stem cell and solid organ transplantation has become increasingly complex as newly discovered HLA alleles are described. HLA typing assignments reported by laboratories are used by physicians and donor registries for matching donors and recipients. To communicate effectively, a common language for histocompatibility terms should be established. In early 2010, representatives from Clinical, Registry, and Histocompatibility organizations joined together as the Harmonization of Histocompatibility Typing Terms Working Group to define a consensual language for laboratories, physicians, and registries to communicate histocompatibility typing information. The Working Group defined terms for HLA typing resolution, HLA matching, and a format for reporting HLA assignments. In addition, definitions of verification typing and extended typing were addressed. The original draft of the Definitions of Histocompatibility Typing Terms was disseminated to colleagues from each organization to gain feedback and create a collaborative document. Commentary gathered during this 90-day review period were discussed and implemented for preparation of this report. Histocompatibility testing continues to evolve; thus, the definitions agreed on today probably will require refinement and perhaps additional terminology in the future.

Original languageEnglish
Pages (from-to)e180-e183
Number of pages4
Issue number23
Publication statusPublished - 1 Dec 2011


  • Allergy and Immunology
  • Guidelines as Topic
  • Histocompatibility
  • Humans
  • Terminology as Topic
  • Transplantation Immunology
  • Consensus Development Conference
  • Journal Article


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