Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Khuloud T. Al-Jamal, Antonio Nunes, Laura Methven, Hanene Ali-Boucetta, Shouping Li, Francesca M. Toma, M. Antonia Herrero, Wafa T. Al-Jamal, Huub M M Tena Eikelder, Julie Foster, Stephen Mather, Maurizio Prato, Alberto Bianco, Kostas Kostarelos

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Original languageEnglish
    Pages (from-to)6389-6393
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Volume51
    Issue number26
    DOIs
    Publication statusPublished - 25 Jun 2012

    Keywords

    • biodistribution
    • functionalization
    • nanotubes
    • pharmacokinetics
    • toxicology

    Fingerprint

    Dive into the research topics of 'Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile'. Together they form a unique fingerprint.

    Cite this