Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19

COVID-HEART investigators, M. Gorecka, G. P. McCann, C. Berry, V. M. Ferreira, J. C. Moon, Christopher Miller, A. Chiribiri, S. Prasad, M. R. Dweck, Chiara Bucciarelli-Ducci, D. Dawson, M. Fontana, P. W. Macfarlane, A. McConnachie, S. Neubauer, J. P. Greenwood

Research output: Contribution to journalArticlepeer-review


Background Although COVID-19 is primarily a respiratory illness, myocardial injury is increasingly reported and associated with adverse outcomes. However, the pathophysiology, extent of myocardial injury and clinical significance remains unclear. Methods COVID-HEART is a UK, multicentre, prospective, observational, longitudinal cohort study of patients with confirmed COVID-19 and elevated troponin (sex-specific >99th centile). Baseline assessment will be whilst recovering in-hospital or recently discharged, and include cardiovascular magnetic resonance (CMR) imaging, quality of life (QoL) assessments, electrocardiogram, serum biomarkers and genetics. Assessment at 6-months includes repeat CMR, QoL assessments and 6-minute walk test (6MWT). The CMR protocol includes cines, T1/T2 mapping, aortic distensibility, late gadolinium enhancement, and adenosine stress myocardial perfusion imaging in selected patients. The main objectives of the study are to: 1) characterise the extent and nature of myocardial involvement in COVID-19 patients with an elevated troponin, 2) assess how cardiac involvement and clinical outcome associate with recognised risk factors for mortality (age, sex, ethnicity and comorbidities) and genetic factors, 3) evaluate if differences in myocardial recovery at 6 months are dependent on demographics, genetics and comorbidities, 4) understand the impact of recovery status at 6 months on patient-reported QoL and functional capacity. Discussion COVID-HEART will provide detailed characterisation of cardiac involvement, and its repair and recovery in relation to comorbidity, genetics, patient-reported QoL measures and functional capacity.
Original languageEnglish
JournalJournal of Cardiovascular Magnetic Resonance
Publication statusAccepted/In press - 2 Apr 2021


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