Dendritic cell research projects.

Pierre Aeby, David Basketter, Walter Diembeck, Dietmar Eschrich, Frank Gerberick, Hiroshi Itagaki, Ian Kimber, Beatrice Le Varlet, Irene Manou, Marc Paye, Francoise Rousset, Joanna Rowland, Hitoshi Sakaguchi

    Research output: Contribution to journalArticlepeer-review


    The Colipa Skin Tolerance Task Force (STTF) is playing an active role in promoting refined methods for in vivo sensitisation tests. Dendritic cells (DCs), whose central role during the induction phase of skin sensitisation is well documented, were perceived as promising in vitro test systems. DC research projects supported by STTF evaluated the relevance of IL-1beta mRNA expression or changes in gene expression using gene microarrays for predicting potential sensitisers. Myeloid cell lines are being evaluated as surrogate DCs. Intracellular signal transduction pathways are being explored in order to understand the underlying biological mechanisms.
    Original languageEnglish
    JournalALTEX : Alternativen zu Tierexperimenten
    Volume23 Suppl
    Publication statusPublished - 2006


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