Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

The Myositis Genetics Consortium (MYOGEN)

doi:10.1136/annrheumdis-2015-208119

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

The Myositis Genetics Consortium (MYOGEN)

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVES: The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. RESULTS: The human leucocyte antigen (HLA) and PTPN22 regions reached genome-wide significance (p

Original language	English
Pages (from-to)	1558-1566
Journal	Annals of the rheumatic diseases
Volume	75
Issue number	8
DOIs	https://doi.org/10.1136/annrheumdis-2015-208119
Publication status	Published - 11 Sept 2015

Keywords

Dermatomyositis
Gene Polymorphism
Polymyositis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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MMRG: Manchester Myositis Research Group
Chinoy, H. (PI), Lamb, J. (PI), Ollier, W. (PI), Rothwell, S. (CoI), Lilleker, J. (CoI), Oldroyd, A. (PGR student), Snedden, A. (PGR student), Platt, H. (Support team) & New, P. (Support team)
1/01/10 → …
Project: Research

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@article{c5479736172248be89058a780baf5743,

title = "Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups",

abstract = "OBJECTIVES: The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. RESULTS: The human leucocyte antigen (HLA) and PTPN22 regions reached genome-wide significance (p",

keywords = "Dermatomyositis, Gene Polymorphism, Polymyositis",

author = "Simon Rothwell and William Ollier and Joanna Cobb and Hazel Platt and Hector Chinoy and Janine Lamb and {The Myositis Genetics Consortium (MYOGEN)}",

year = "2015",

month = sep,

day = "11",

doi = "10.1136/annrheumdis-2015-208119",

language = "English",

volume = "75",

pages = "1558--1566",

journal = "Annals of the rheumatic diseases",

issn = "1468-2060",

publisher = "Elsevier BV",

number = "8",

}

The Myositis Genetics Consortium (MYOGEN) 2015, 'Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups', Annals of the rheumatic diseases, vol. 75, no. 8, pp. 1558-1566. https://doi.org/10.1136/annrheumdis-2015-208119

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups. / The Myositis Genetics Consortium (MYOGEN) .
In: Annals of the rheumatic diseases, Vol. 75, No. 8, 11.09.2015, p. 1558-1566.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

AU - Ollier, William

AU - Cobb, Joanna

AU - Platt, Hazel

AU - Chinoy, Hector

AU - Lamb, Janine

AU - The Myositis Genetics Consortium (MYOGEN)

A2 - Rothwell, Simon

PY - 2015/9/11

Y1 - 2015/9/11

N2 - OBJECTIVES: The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. RESULTS: The human leucocyte antigen (HLA) and PTPN22 regions reached genome-wide significance (p

AB - OBJECTIVES: The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare autoimmune diseases characterised by muscle weakness and extramuscular manifestations such as skin rashes and interstitial lung disease. We genotyped 2566 IIM cases of Caucasian descent using the Immunochip; a custom array covering 186 established autoimmune susceptibility loci. The cohort was predominantly comprised of patients with dermatomyositis (DM, n=879), juvenile DM (JDM, n=481), polymyositis (PM, n=931) and inclusion body myositis (n=252) collected from 14 countries through the Myositis Genetics Consortium. RESULTS: The human leucocyte antigen (HLA) and PTPN22 regions reached genome-wide significance (p

KW - Dermatomyositis

KW - Gene Polymorphism

KW - Polymyositis

U2 - 10.1136/annrheumdis-2015-208119

DO - 10.1136/annrheumdis-2015-208119

M3 - Article

C2 - 26362759

SN - 1468-2060

VL - 75

SP - 1558

EP - 1566

JO - Annals of the rheumatic diseases

JF - Annals of the rheumatic diseases

IS - 8

ER -

Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

Abstract

Keywords

UN SDGs

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MMRG: Manchester Myositis Research Group

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