Design and engineering of multifunctional quantum dot-based nanoparticles for simultaneous therapeutic-diagnostic applications

Bowen Tian; Wafa' T Al-Jamal; Jeroen Van den Bossche; Kostas Kostarelos

doi:10.1007/978-1-4614-2305-8_16

Design and engineering of multifunctional quantum dot-based nanoparticles for simultaneous therapeutic-diagnostic applications

Bowen Tian, Wafa' T Al-Jamal, Jeroen Van den Bossche, Kostas Kostarelos

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

Abstract

Quantum dots (QD) are semiconducting nanocrystals that have recently received a lot of interest because of their efficacy as fluorescent probes. They offer a significant increase in photostability and fluorescence lifetime compared to more traditional organic dye-based probes; however, some concern from their potential in vivo use due to their chemical composition and their nanoscale dimensions exists. Within this chapter, we discuss current knowledge about the fluorescence properties and pharmacological profile of quantum dots, showing how these characteristics can be altered after incorporation within previously established drug delivery systems for the formation of novel hybrid systems. The incorporation of therapeutic agents into such hybrid systems can further result in the construction of theranostic devices, namely, QD-based theranostics. Alternatively, conjugation of quantum dots to therapeutic moieties can be used as a scaffold for theranostic device design. This chapter will discuss the current progress in QD-based theranostics.

Original language	English
Title of host publication	Multifunctional Nanoparticles for Drug Delivery Applications
Subtitle of host publication	Imaging, Targeting, and Delivery
Editors	Sonke Svenson, Robert K. Prud'homme
Publisher	Springer Nature
Chapter	16
Pages	345-365
Number of pages	21
ISBN (Electronic)	9781461423058
ISBN (Print)	9781461423041
DOIs	https://doi.org/10.1007/978-1-4614-2305-8_16
Publication status	Published - 2012

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10.1007/978-1-4614-2305-8_16

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Tian, B., Al-Jamal, W. T., Van den Bossche, J., & Kostarelos, K. (2012). Design and engineering of multifunctional quantum dot-based nanoparticles for simultaneous therapeutic-diagnostic applications. In S. Svenson, & R. K. Prud'homme (Eds.), Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting, and Delivery (pp. 345-365). Springer Nature. https://doi.org/10.1007/978-1-4614-2305-8_16

Tian, Bowen ; Al-Jamal, Wafa' T ; Van den Bossche, Jeroen et al. / Design and engineering of multifunctional quantum dot-based nanoparticles for simultaneous therapeutic-diagnostic applications. Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting, and Delivery. editor / Sonke Svenson ; Robert K. Prud'homme. Springer Nature, 2012. pp. 345-365

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abstract = "Quantum dots (QD) are semiconducting nanocrystals that have recently received a lot of interest because of their efficacy as fluorescent probes. They offer a significant increase in photostability and fluorescence lifetime compared to more traditional organic dye-based probes; however, some concern from their potential in vivo use due to their chemical composition and their nanoscale dimensions exists. Within this chapter, we discuss current knowledge about the fluorescence properties and pharmacological profile of quantum dots, showing how these characteristics can be altered after incorporation within previously established drug delivery systems for the formation of novel hybrid systems. The incorporation of therapeutic agents into such hybrid systems can further result in the construction of theranostic devices, namely, QD-based theranostics. Alternatively, conjugation of quantum dots to therapeutic moieties can be used as a scaffold for theranostic device design. This chapter will discuss the current progress in QD-based theranostics.",

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Tian, B, Al-Jamal, WT, Van den Bossche, J & Kostarelos, K 2012, Design and engineering of multifunctional quantum dot-based nanoparticles for simultaneous therapeutic-diagnostic applications. in S Svenson & RK Prud'homme (eds), Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting, and Delivery. Springer Nature, pp. 345-365. https://doi.org/10.1007/978-1-4614-2305-8_16

Design and engineering of multifunctional quantum dot-based nanoparticles for simultaneous therapeutic-diagnostic applications. / Tian, Bowen; Al-Jamal, Wafa' T; Van den Bossche, Jeroen et al.
Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting, and Delivery. ed. / Sonke Svenson; Robert K. Prud'homme. Springer Nature, 2012. p. 345-365.

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

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Tian B, Al-Jamal WT, Van den Bossche J, Kostarelos K. Design and engineering of multifunctional quantum dot-based nanoparticles for simultaneous therapeutic-diagnostic applications. In Svenson S, Prud'homme RK, editors, Multifunctional Nanoparticles for Drug Delivery Applications: Imaging, Targeting, and Delivery. Springer Nature. 2012. p. 345-365 doi: 10.1007/978-1-4614-2305-8_16

Design and engineering of multifunctional quantum dot-based nanoparticles for simultaneous therapeutic-diagnostic applications

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