Design and physiology of the heart | Cardiac Excitation-Contraction Coupling: Routes of Cellular Calcium Flux

H. A. Shiels

doi:10.1016/B978-0-12-374553-8.00175-1

Design and physiology of the heart | Cardiac Excitation-Contraction Coupling: Routes of Cellular Calcium Flux

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

Abstract

When an action potential excites a fish cardiac myocyte it causes intracellular calcium (Ca) levels to rise initiating contraction. This sequence of events is termed 'excitation-contraction coupling'. To end contraction and begin relaxation, Ca levels inside the myocyte must fall. This transient rise and fall of Ca with each contraction-relaxation cycle is called the 'Ca transient'. A contraction-relaxation cycle is the cellular equivalent of the heartbeat. The rate and magnitude of the Ca transient determines the rate and strength of heart contraction. In fish, the Ca fluxes that generate this Ca transient can be of both extra- or intracellular origin and are regulated to adjust cardiac function in a response to a change in physiological demand. © 2011 Elsevier Inc. All rights reserved.

Original language	English
Title of host publication	Encyclopedia of Fish Physiology\|Encyclopedia of Fish Physiol.
Place of Publication	San Diego
Publisher	Elsevier BV
Pages	1045-1053
Number of pages	8
Volume	2
DOIs	https://doi.org/10.1016/B978-0-12-374553-8.00175-1
Publication status	Published - 2011

Keywords

[Ca2+]i
Adrenaline
Ca transient
Excitation-contraction coupling
L-type Ca channel
Myocyte
Na-Ca exchanger
Sarcoplasmic reticulum
Temperature

Access to Document

10.1016/B978-0-12-374553-8.00175-1

Cite this

@inbook{f9b37fe454a94d72a3e38be39aab9f23,

title = "Design and physiology of the heart | Cardiac Excitation-Contraction Coupling: Routes of Cellular Calcium Flux",

abstract = "When an action potential excites a fish cardiac myocyte it causes intracellular calcium (Ca) levels to rise initiating contraction. This sequence of events is termed 'excitation-contraction coupling'. To end contraction and begin relaxation, Ca levels inside the myocyte must fall. This transient rise and fall of Ca with each contraction-relaxation cycle is called the 'Ca transient'. A contraction-relaxation cycle is the cellular equivalent of the heartbeat. The rate and magnitude of the Ca transient determines the rate and strength of heart contraction. In fish, the Ca fluxes that generate this Ca transient can be of both extra- or intracellular origin and are regulated to adjust cardiac function in a response to a change in physiological demand. {\textcopyright} 2011 Elsevier Inc. All rights reserved.",

keywords = "[Ca2+]i, Adrenaline, Ca transient, Excitation-contraction coupling, L-type Ca channel, Myocyte, Na-Ca exchanger, Sarcoplasmic reticulum, Temperature",

author = "Shiels, {H. A.}",

year = "2011",

doi = "10.1016/B978-0-12-374553-8.00175-1",

language = "English",

volume = "2",

pages = "1045--1053",

booktitle = "Encyclopedia of Fish Physiology|Encyclopedia of Fish Physiol.",

publisher = "Elsevier BV",

address = "Netherlands",

}

TY - CHAP

T1 - Design and physiology of the heart | Cardiac Excitation-Contraction Coupling: Routes of Cellular Calcium Flux

AU - Shiels, H. A.

PY - 2011

Y1 - 2011

N2 - When an action potential excites a fish cardiac myocyte it causes intracellular calcium (Ca) levels to rise initiating contraction. This sequence of events is termed 'excitation-contraction coupling'. To end contraction and begin relaxation, Ca levels inside the myocyte must fall. This transient rise and fall of Ca with each contraction-relaxation cycle is called the 'Ca transient'. A contraction-relaxation cycle is the cellular equivalent of the heartbeat. The rate and magnitude of the Ca transient determines the rate and strength of heart contraction. In fish, the Ca fluxes that generate this Ca transient can be of both extra- or intracellular origin and are regulated to adjust cardiac function in a response to a change in physiological demand. © 2011 Elsevier Inc. All rights reserved.

AB - When an action potential excites a fish cardiac myocyte it causes intracellular calcium (Ca) levels to rise initiating contraction. This sequence of events is termed 'excitation-contraction coupling'. To end contraction and begin relaxation, Ca levels inside the myocyte must fall. This transient rise and fall of Ca with each contraction-relaxation cycle is called the 'Ca transient'. A contraction-relaxation cycle is the cellular equivalent of the heartbeat. The rate and magnitude of the Ca transient determines the rate and strength of heart contraction. In fish, the Ca fluxes that generate this Ca transient can be of both extra- or intracellular origin and are regulated to adjust cardiac function in a response to a change in physiological demand. © 2011 Elsevier Inc. All rights reserved.

KW - [Ca2+]i

KW - Adrenaline

KW - Ca transient

KW - Excitation-contraction coupling

KW - L-type Ca channel

KW - Myocyte

KW - Na-Ca exchanger

KW - Sarcoplasmic reticulum

KW - Temperature

U2 - 10.1016/B978-0-12-374553-8.00175-1

DO - 10.1016/B978-0-12-374553-8.00175-1

M3 - Entry for encyclopedia/dictionary

VL - 2

SP - 1045

EP - 1053

BT - Encyclopedia of Fish Physiology|Encyclopedia of Fish Physiol.

PB - Elsevier BV

CY - San Diego

ER -

Design and physiology of the heart | Cardiac Excitation-Contraction Coupling: Routes of Cellular Calcium Flux

Abstract

Keywords

Access to Document

Fingerprint

Cite this