Design of experiments as a tool for LC–MS/MS method development for the trace analysis of the potentially genotoxic 4-dimethylaminopyridine impurity in glucocorticoids

Gyorgy Szekely; Bruno Henriques; Marco Gil; Antonio Ramos; Carlos Alvarez

doi:10.1016/j.jpba.2012.07.006

Design of experiments as a tool for LC–MS/MS method development for the trace analysis of the potentially genotoxic 4-dimethylaminopyridine impurity in glucocorticoids

Gyorgy Szekely, Bruno Henriques, Marco Gil, Antonio Ramos, Carlos Alvarez

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	251-258
Number of pages	7
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	70
DOIs	https://doi.org/10.1016/j.jpba.2012.07.006
Publication status	Published - 14 Jul 2012

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10.1016/j.jpba.2012.07.006

http://www.sciencedirect.com/science/article/pii/S0731708512003810

Cite this

@article{14eddc46ae8b4a5baeec8c0936bbf86b,

title = "Design of experiments as a tool for LC–MS/MS method development for the trace analysis of the potentially genotoxic 4-dimethylaminopyridine impurity in glucocorticoids",

author = "Gyorgy Szekely and Bruno Henriques and Marco Gil and Antonio Ramos and Carlos Alvarez",

note = "The authors wish to acknowledge the financial support of the European Commission under FP7-Marie Curie Actions, contract PITN-GA-2008-214226 [NEMOPUR] for the work described in this paper.",

year = "2012",

month = jul,

day = "14",

doi = "10.1016/j.jpba.2012.07.006",

language = "English",

volume = "70",

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journal = "Journal of Pharmaceutical and Biomedical Analysis",

issn = "0731-7085",

publisher = "Elsevier BV",

}

Design of experiments as a tool for LC–MS/MS method development for the trace analysis of the potentially genotoxic 4-dimethylaminopyridine impurity in glucocorticoids. / Szekely, Gyorgy; Henriques, Bruno; Gil, Marco et al.
In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 70, 14.07.2012, p. 251-258.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Design of experiments as a tool for LC–MS/MS method development for the trace analysis of the potentially genotoxic 4-dimethylaminopyridine impurity in glucocorticoids

AU - Szekely, Gyorgy

AU - Henriques, Bruno

AU - Gil, Marco

AU - Ramos, Antonio

AU - Alvarez, Carlos

N1 - The authors wish to acknowledge the financial support of the European Commission under FP7-Marie Curie Actions, contract PITN-GA-2008-214226 [NEMOPUR] for the work described in this paper.

PY - 2012/7/14

Y1 - 2012/7/14

U2 - 10.1016/j.jpba.2012.07.006

DO - 10.1016/j.jpba.2012.07.006

M3 - Article

SN - 0731-7085

VL - 70

SP - 251

EP - 258

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

ER -