Design, synthesis and assaying of potential aquaporin inhibitors

Sabine L. Flitsch; Rose Haddoub; Michael Rützler; Aélig Robin

doi:10.1007/978-3-540-79885-9_19

Design, synthesis and assaying of potential aquaporin inhibitors

Sabine L. Flitsch, Rose Haddoub, Michael Rützler, Aélig Robin

Research output: Chapter in Book/Conference proceeding › Chapter

Abstract

The aquaporin protein family performs fundamental tasks in the physiology of several organs in the human body. Their roles in several disorders known to involve water movement make them attractive targets for the development of novel drug therapies. This chapter describes assays commonly used to study the water permeability across AQPs. It also describes the effect of some known inhibitors of aquaporins on water permeability, such as mercury, gold, silver, copper, phloretin, tetraethyl ammonium salts and acetazolamide compounds. © 2009 Springer Berlin Heidelberg.

Original language	English
Title of host publication	Handbook of Experimental Pharmacology\|Handb. Exp. Pharmacol.
Place of Publication	Berlin, New York
Publisher	Springer Nature
Pages	385-402
Number of pages	17
Volume	190
DOIs	https://doi.org/10.1007/978-3-540-79885-9_19
Publication status	Published - 2009

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10.1007/978-3-540-79885-9_19

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abstract = "The aquaporin protein family performs fundamental tasks in the physiology of several organs in the human body. Their roles in several disorders known to involve water movement make them attractive targets for the development of novel drug therapies. This chapter describes assays commonly used to study the water permeability across AQPs. It also describes the effect of some known inhibitors of aquaporins on water permeability, such as mercury, gold, silver, copper, phloretin, tetraethyl ammonium salts and acetazolamide compounds. {\textcopyright} 2009 Springer Berlin Heidelberg.",

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AB - The aquaporin protein family performs fundamental tasks in the physiology of several organs in the human body. Their roles in several disorders known to involve water movement make them attractive targets for the development of novel drug therapies. This chapter describes assays commonly used to study the water permeability across AQPs. It also describes the effect of some known inhibitors of aquaporins on water permeability, such as mercury, gold, silver, copper, phloretin, tetraethyl ammonium salts and acetazolamide compounds. © 2009 Springer Berlin Heidelberg.

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BT - Handbook of Experimental Pharmacology|Handb. Exp. Pharmacol.

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ER -

Design, synthesis and assaying of potential aquaporin inhibitors

Abstract

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