Designation of substances as skin sensitizing chemicals: A commentary

Ian Kimber, R. J. Dearman, G. F. Gerberick, R. Roggeband, D. A. Basketter

    Research output: Contribution to journalArticlepeer-review


    During the last 10 years there have been several aftempts to define criteria for the integration of experimental and clinical data into schemes that can be used for the designation of chemicals as skin sensitizers (and in some instances respiratory allergens). The last such proposal was made recently in this journal by Schnuch and colleagues (Hum Exp Toxicol 2002; 2: 439-44) who invited critical discussion and debate of the area. In this present article we have sought to build upon and refine further those previous recommendations and suggest here a modified scheme for the classification of chemicals as confirmed or probable skin sensitizers. This new scheme we believe provides a realistic framework within which informed decisions can be reached about likely skin sensitizing activity based upon judicious consideration of clinical and experimental information.
    Original languageEnglish
    Pages (from-to)439-443
    Number of pages4
    JournalHuman and Experimental Toxicology
    Issue number8
    Publication statusPublished - 1 Aug 2003


    • Allergic contact dermatitis
    • Classification
    • Predictive tests
    • Skin sensitization


    Dive into the research topics of 'Designation of substances as skin sensitizing chemicals: A commentary'. Together they form a unique fingerprint.

    Cite this