Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

Sarah K. Runswick; Mike J. O'hare; Louise Jones; Charles H. Streuli; David R. Garrod

doi:10.1038/ncb0901-823

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

Sarah K. Runswick, Mike J. O'hare, Louise Jones, Charles H. Streuli, David R. Garrod

Research output: Contribution to journal › Article › peer-review

Abstract

Desmosomes are intercellular junctions of epithelia and are of widespread importance in the maintenance of tissue architecture. We provide evidence that desmosomal adhesion has a function in epithelial morphogenesis and cell-type-specific positioning. Blocking peptides corresponding to the cell adhesion recognition (CAR) sites of desmosomal cadherins block alveolar morphogenesis by epithelial cells from mammary lumen. Desmosomal CAR-site peptides also disrupt positional sorting of luminal and myoepithelial cells in aggregates formed by the reassociation of isolated cells. We demonstrate that desmosomal cadherins and E-cadherin are comparably involved in epithelial morphoregulation. The results indicate a wider role for desmosomal adhesion in morphogenesis than has previously been considered.

Original language	English
Pages (from-to)	823-830
Number of pages	7
Journal	Nature Cell Biology
Volume	3
Issue number	9
DOIs	https://doi.org/10.1038/ncb0901-823
Publication status	Published - 2001

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title = "Desmosomal adhesion regulates epithelial morphogenesis and cell positioning",

abstract = "Desmosomes are intercellular junctions of epithelia and are of widespread importance in the maintenance of tissue architecture. We provide evidence that desmosomal adhesion has a function in epithelial morphogenesis and cell-type-specific positioning. Blocking peptides corresponding to the cell adhesion recognition (CAR) sites of desmosomal cadherins block alveolar morphogenesis by epithelial cells from mammary lumen. Desmosomal CAR-site peptides also disrupt positional sorting of luminal and myoepithelial cells in aggregates formed by the reassociation of isolated cells. We demonstrate that desmosomal cadherins and E-cadherin are comparably involved in epithelial morphoregulation. The results indicate a wider role for desmosomal adhesion in morphogenesis than has previously been considered.",

author = "Runswick, {Sarah K.} and O'hare, {Mike J.} and Louise Jones and Streuli, {Charles H.} and Garrod, {David R.}",

year = "2001",

doi = "10.1038/ncb0901-823",

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T1 - Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

AU - Runswick, Sarah K.

AU - O'hare, Mike J.

AU - Jones, Louise

AU - Streuli, Charles H.

AU - Garrod, David R.

PY - 2001

Y1 - 2001

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AB - Desmosomes are intercellular junctions of epithelia and are of widespread importance in the maintenance of tissue architecture. We provide evidence that desmosomal adhesion has a function in epithelial morphogenesis and cell-type-specific positioning. Blocking peptides corresponding to the cell adhesion recognition (CAR) sites of desmosomal cadherins block alveolar morphogenesis by epithelial cells from mammary lumen. Desmosomal CAR-site peptides also disrupt positional sorting of luminal and myoepithelial cells in aggregates formed by the reassociation of isolated cells. We demonstrate that desmosomal cadherins and E-cadherin are comparably involved in epithelial morphoregulation. The results indicate a wider role for desmosomal adhesion in morphogenesis than has previously been considered.

U2 - 10.1038/ncb0901-823

DO - 10.1038/ncb0901-823

M3 - Article

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SN - 1465-7392

VL - 3

SP - 823

EP - 830

JO - Nature Cell Biology

JF - Nature Cell Biology

IS - 9

ER -

Desmosomal adhesion regulates epithelial morphogenesis and cell positioning

Abstract

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