Desmosomal cadherins

David R. Garrod; Anita J. Merritt; Zhuxiang Nie

doi:10.1016/S0955-0674(02)00366-6

Desmosomal cadherins

David R. Garrod, Anita J. Merritt, Zhuxiang Nie

Research output: Contribution to journal › Article › peer-review

Abstract

New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.

Original language	English
Pages (from-to)	537-545
Number of pages	8
Journal	Curr Opin Cell Biol
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/S0955-0674(02)00366-6
Publication status	Published - Oct 2002

Keywords

Animals
chemistry: Cadherins
Cell Adhesion
metabolism: Desmosomes
metabolism: Epidermis
Genotype
Humans
Mice
Mice, Knockout
Models, Biological
Phenotype
Protein Binding

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0955-0674(02)00366-6

Cite this

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title = "Desmosomal cadherins",

abstract = "New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.",

keywords = "Animals, chemistry: Cadherins, Cell Adhesion, metabolism: Desmosomes, metabolism: Epidermis, Genotype, Humans, Mice, Mice, Knockout, Models, Biological, Phenotype, Protein Binding",

author = "Garrod, {David R.} and Merritt, {Anita J.} and Zhuxiang Nie",

year = "2002",

month = oct,

doi = "10.1016/S0955-0674(02)00366-6",

language = "English",

volume = "14",

pages = "537--545",

journal = "Curr Opin Cell Biol",

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TY - JOUR

T1 - Desmosomal cadherins

AU - Garrod, David R.

AU - Merritt, Anita J.

AU - Nie, Zhuxiang

PY - 2002/10

Y1 - 2002/10

N2 - New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.

AB - New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.

KW - Animals

KW - chemistry: Cadherins

KW - Cell Adhesion

KW - metabolism: Desmosomes

KW - metabolism: Epidermis

KW - Genotype

KW - Humans

KW - Mice

KW - Mice, Knockout

KW - Models, Biological

KW - Phenotype

KW - Protein Binding

U2 - 10.1016/S0955-0674(02)00366-6

DO - 10.1016/S0955-0674(02)00366-6

M3 - Article

SN - 0955-0674

VL - 14

SP - 537

EP - 545

JO - Curr Opin Cell Biol

JF - Curr Opin Cell Biol

IS - 5

ER -

Desmosomal cadherins

Abstract

Keywords

UN SDGs

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