Desmosomal cadherins

David R. Garrod, Anita J. Merritt, Zhuxiang Nie

    Research output: Contribution to journalArticlepeer-review


    New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.
    Original languageEnglish
    Pages (from-to)537-545
    Number of pages8
    JournalCurr Opin Cell Biol
    Issue number5
    Publication statusPublished - Oct 2002


    • Animals
    • chemistry: Cadherins
    • Cell Adhesion
    • metabolism: Desmosomes
    • metabolism: Epidermis
    • Genotype
    • Humans
    • Mice
    • Mice, Knockout
    • Models, Biological
    • Phenotype
    • Protein Binding


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