Abstract
PURPOSE: The aim of the study was to investigate the feasibility of (18)F-3'-fluoro-3'-deoxy-L-thymidine positron emission tomography (FLT-PET) for the detection and grading of soft tissue sarcoma (STS).
EXPERIMENTAL DESIGN: Nineteen patients with 20 STSs of the extremities were scanned, using attenuation corrected whole-body FLT-PET. Standardized uptake values (SUVs) and tumor:nontumor ratios (TNTs) were compared with histopathological parameters using French and Japanese grading systems.
RESULTS: Mean SUV, maximal SUV, and TNT could differentiate between low-grade (grade 1; n = 6) STS and high-grade (grade 2 and 3; n = 14) STS according to the French grading system (P = 0.001). Mean SUV, max SUV, and TNT correlated with mitotic score, MIB-1 score, the French and Japanese grading system (* = 0.550-0.747).
CONCLUSIONS: FLT-PET is able to visualize STS and differentiate between low-grade and high-grade STS. The uptake of FLT correlates with the proliferation of STS.
| Original language | English |
|---|---|
| Pages (from-to) | 1685-1690 |
| Number of pages | 6 |
| Journal | Clinical Cancer Research |
| Volume | 10 |
| Issue number | 5 |
| Publication status | Published - 1 Mar 2004 |
Keywords
- Aged
- Dideoxynucleosides
- Female
- Fluorine Radioisotopes
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Sarcoma
- Soft Tissue Neoplasms
- Tissue Distribution
- Tomography, Emission-Computed
- Journal Article
