Detection and investigation of invasive mould disease

Manuel Cuenca-Estrella; Matteo Bassetti; Cornelia Lass-Flörl; Zdeněk Ráčil; Malcolm Richardson; Thomas R. Rogers

doi:10.1093/jac/dkq438

Detection and investigation of invasive mould disease

Manuel Cuenca-Estrella, Matteo Bassetti, Cornelia Lass-Flörl, Zdeněk Ráčil, Malcolm Richardson, Thomas R. Rogers

Research output: Contribution to journal › Article › peer-review

Abstract

A comprehensive review of diagnostic techniques for opportunistic systemic mycoses focused on invasive mould disease in immunocompromised patients is presented. We first analysed conventional diagnostic methods, such as microscopy examination, culture and radiology, underlining their limitations, which have led to the development of alternative methods, such as the detection of fungal components. Among these we highlight fungal antigen and DNA quantification, which make it possible to detect infections early and start appropriate treatment. We also briefly review the methods for carrying out susceptibility tests for antifungal drugs, including reference procedures, commercial techniques and their indications. Furthermore, we analyse the recommendations for therapeutic drug monitoring of antifungal agents in body fluids. © The Author 2011. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

Original language	English
Article number	dkq438
Pages (from-to)	15-24
Number of pages	9
Journal	Journal of Antimicrobial Chemotherapy
Volume	66
Issue number	1
DOIs	https://doi.org/10.1093/jac/dkq438
Publication status	Published - Jan 2011

Keywords

β-D-glucan
Cultures
Galactomannan
Microscopic examination
PCR-based diagnosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Detection and investigation of invasive mould disease",

abstract = "A comprehensive review of diagnostic techniques for opportunistic systemic mycoses focused on invasive mould disease in immunocompromised patients is presented. We first analysed conventional diagnostic methods, such as microscopy examination, culture and radiology, underlining their limitations, which have led to the development of alternative methods, such as the detection of fungal components. Among these we highlight fungal antigen and DNA quantification, which make it possible to detect infections early and start appropriate treatment. We also briefly review the methods for carrying out susceptibility tests for antifungal drugs, including reference procedures, commercial techniques and their indications. Furthermore, we analyse the recommendations for therapeutic drug monitoring of antifungal agents in body fluids. {\textcopyright} The Author 2011. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.",

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AU - Cuenca-Estrella, Manuel

AU - Bassetti, Matteo

AU - Lass-Flörl, Cornelia

AU - Ráčil, Zdeněk

AU - Richardson, Malcolm

AU - Rogers, Thomas R.

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N2 - A comprehensive review of diagnostic techniques for opportunistic systemic mycoses focused on invasive mould disease in immunocompromised patients is presented. We first analysed conventional diagnostic methods, such as microscopy examination, culture and radiology, underlining their limitations, which have led to the development of alternative methods, such as the detection of fungal components. Among these we highlight fungal antigen and DNA quantification, which make it possible to detect infections early and start appropriate treatment. We also briefly review the methods for carrying out susceptibility tests for antifungal drugs, including reference procedures, commercial techniques and their indications. Furthermore, we analyse the recommendations for therapeutic drug monitoring of antifungal agents in body fluids. © The Author 2011. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

AB - A comprehensive review of diagnostic techniques for opportunistic systemic mycoses focused on invasive mould disease in immunocompromised patients is presented. We first analysed conventional diagnostic methods, such as microscopy examination, culture and radiology, underlining their limitations, which have led to the development of alternative methods, such as the detection of fungal components. Among these we highlight fungal antigen and DNA quantification, which make it possible to detect infections early and start appropriate treatment. We also briefly review the methods for carrying out susceptibility tests for antifungal drugs, including reference procedures, commercial techniques and their indications. Furthermore, we analyse the recommendations for therapeutic drug monitoring of antifungal agents in body fluids. © The Author 2011. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

KW - β-D-glucan

KW - Cultures

KW - Galactomannan

KW - Microscopic examination

KW - PCR-based diagnosis

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DO - 10.1093/jac/dkq438

M3 - Article

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SN - 0305-7453

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SP - 15

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JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

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Detection and investigation of invasive mould disease

Abstract

Keywords

UN SDGs

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