Detection of circulating antigen of Aspergillus fumigatus in sera of mice and rabbits by enzyme-linked immunosorbent assay

M. D. Richardson, L. O. White, R. C. Warren

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Circulating antigen of Aspergillus fumigatus was demonstrated in the sera of experimentally infected, cortisone-treated mice and rabbits by enzyme-linked immunosorbent assay (micro-ELISA), confirming earlier results where fungal antigen had been detected by counter-immunoelectrophoresis (CIE). Peaks of detection of circulating antigen by CIE and micro-ELISA in mice were not simultaneous suggesting that the nature of the predominant antigens may have altered during the course of infection. CIE failed to detect fungal antigen in infected rabbits whereas micro-ELISA monitored antigenemia until death. Both CIE and micro-ELISA demonstrated the rapid clearance of intravenously inoculated Aspergillus-antigen from the rabbit circulation. © 1979 Dr. W. Junk b.v.
    Original languageEnglish
    Pages (from-to)83-88
    Number of pages5
    JournalMycopathologia
    Volume67
    Issue number2
    DOIs
    Publication statusPublished - Jan 1979

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