Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI

Helen Marshall; Alexander Horsley; Chris J  Taylor; Laurie  Smith; David Hughes; Felix C  Horn; Andrew J  Swift; Juan  Parra-Robles; Paul J  Hughes; Graham  Norquay; Neil J.  Stewart; Guilhem J  Collier; Dawn  Teare; Steve Cunningham; Ina  Aldag; Jim M Wild

doi:10.1136/thoraxjnl-2016-208948

Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI

Helen Marshall, Alexander Horsley, Chris J Taylor, Laurie Smith, David Hughes, Felix C Horn, Andrew J Swift, Juan Parra-Robles, Paul J Hughes, Graham Norquay, Neil J. Stewart, Guilhem J Collier, Dawn Teare, Steve Cunningham, Ina Aldag, Jim M Wild

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

62 Downloads (Pure)

Abstract

Hyperpolarised He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6–16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>−1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure–function relationships.

Original language	English
Pages (from-to)	760-762
Journal	Thorax
Volume	72
Issue number	8
Early online date	6 Mar 2017
DOIs	https://doi.org/10.1136/thoraxjnl-2016-208948
Publication status	Published - 6 Mar 2017

Keywords

Cystic fibrosis
Magnetic Resonance Imaging
Computed tomography
Multiple Breath Washout
Hyperpolarized gas MRI

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/thoraxjnl-2016-208948

R3 HeMRI CF manuscript thorax RESEARCH LETTERAccepted author manuscript, 2.78 MB

Cite this

Marshall, H., Horsley, A., Taylor, C. J., Smith, L., Hughes, D., Horn, F. C., Swift, A. J., Parra-Robles, J., Hughes, P. J., Norquay, G., Stewart, N. J., Collier, G. J., Teare, D., Cunningham, S., Aldag, I., & Wild, J. M. (2017). Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI. Thorax, 72(8), 760-762. https://doi.org/10.1136/thoraxjnl-2016-208948

@article{e9910dde2f9f4870a821443c2c45b3b6,

title = "Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI",

abstract = "Hyperpolarised He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6–16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>−1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89\% of patients with CF, compared with CT abnormalities in 68\%, LCI 47\% and conventional MRI 22\%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure–function relationships.",

keywords = "Cystic fibrosis, Magnetic Resonance Imaging, Computed tomography, Multiple Breath Washout, Hyperpolarized gas MRI",

author = "Helen Marshall and Alexander Horsley and Taylor, \{Chris J\} and Laurie Smith and David Hughes and Horn, \{Felix C\} and Swift, \{Andrew J\} and Juan Parra-Robles and Hughes, \{Paul J\} and Graham Norquay and Stewart, \{Neil J.\} and Collier, \{Guilhem J\} and Dawn Teare and Steve Cunningham and Ina Aldag and Wild, \{Jim M\}",

year = "2017",

month = mar,

day = "6",

doi = "10.1136/thoraxjnl-2016-208948",

language = "English",

volume = "72",

pages = "760--762",

journal = "Thorax",

issn = "0040-6376",

publisher = "BMJ ",

number = "8",

}

Marshall, H, Horsley, A, Taylor, CJ, Smith, L, Hughes, D, Horn, FC, Swift, AJ, Parra-Robles, J, Hughes, PJ, Norquay, G, Stewart, NJ, Collier, GJ, Teare, D, Cunningham, S, Aldag, I & Wild, JM 2017, 'Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI', Thorax, vol. 72, no. 8, pp. 760-762. https://doi.org/10.1136/thoraxjnl-2016-208948

TY - JOUR

T1 - Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI

AU - Marshall, Helen

AU - Horsley, Alexander

AU - Taylor, Chris J

AU - Smith, Laurie

AU - Hughes, David

AU - Horn, Felix C

AU - Swift, Andrew J

AU - Parra-Robles, Juan

AU - Hughes, Paul J

AU - Norquay, Graham

AU - Stewart, Neil J.

AU - Collier, Guilhem J

AU - Teare, Dawn

AU - Cunningham, Steve

AU - Aldag, Ina

AU - Wild, Jim M

PY - 2017/3/6

Y1 - 2017/3/6

N2 - Hyperpolarised He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6–16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>−1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure–function relationships.

AB - Hyperpolarised He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6–16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>−1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure–function relationships.

KW - Cystic fibrosis

KW - Magnetic Resonance Imaging

KW - Computed tomography

KW - Multiple Breath Washout

KW - Hyperpolarized gas MRI

U2 - 10.1136/thoraxjnl-2016-208948

DO - 10.1136/thoraxjnl-2016-208948

M3 - Article

SN - 0040-6376

VL - 72

SP - 760

EP - 762

JO - Thorax

JF - Thorax

IS - 8

ER -

Detection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this