Detection of the interleukin 18 family in rat brain by RT-PCR

Rachel D. Wheeler; Aedin C. Culhane; Matthew D. Hall; Stuart Pickering-Brown; Nancy J. Rothwell; Giamal N. Luheshi

doi:10.1016/S0169-328X(00)00069-3

Detection of the interleukin 18 family in rat brain by RT-PCR

Rachel D. Wheeler, Aedin C. Culhane, Matthew D. Hall, Stuart Pickering-Brown, Nancy J. Rothwell, Giamal N. Luheshi

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Abstract

Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL- 18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BP), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	290-293
Number of pages	3
Journal	Molecular Brain Research
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/S0169-328X(00)00069-3
Publication status	Published - 5 May 2000

Keywords

AcPL
Binding protein
Hypothalamus
Interleukin 18
RT-PCR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0169-328X(00)00069-3

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title = "Detection of the interleukin 18 family in rat brain by RT-PCR",

abstract = "Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL- 18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BP), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR. (C) 2000 Elsevier Science B.V.",

keywords = "AcPL, Binding protein, Hypothalamus, Interleukin 18, RT-PCR",

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T1 - Detection of the interleukin 18 family in rat brain by RT-PCR

AU - Wheeler, Rachel D.

AU - Culhane, Aedin C.

AU - Hall, Matthew D.

AU - Pickering-Brown, Stuart

AU - Rothwell, Nancy J.

AU - Luheshi, Giamal N.

PY - 2000/5/5

Y1 - 2000/5/5

N2 - Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL- 18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BP), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR. (C) 2000 Elsevier Science B.V.

AB - Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL- 18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BP), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR. (C) 2000 Elsevier Science B.V.

KW - AcPL

KW - Binding protein

KW - Hypothalamus

KW - Interleukin 18

KW - RT-PCR

U2 - 10.1016/S0169-328X(00)00069-3

DO - 10.1016/S0169-328X(00)00069-3

M3 - Article

SN - 1872-6941

VL - 77

SP - 290

EP - 293

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 2

ER -

Detection of the interleukin 18 family in rat brain by RT-PCR

Abstract

Keywords

UN SDGs

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