Determination of molecular hydration in solution via changes in magnetic anisotropy

Marcus J. Giansiracusa; Michele Vonci; Yasmin L. Whyatt; Carys Williams; Kevin  Mason; David Parker; Eric J. L. Mcinnes; Nicholas F. Chilton

doi:10.1039/D3CC00601H

Determination of molecular hydration in solution via changes in magnetic anisotropy

Marcus J. Giansiracusa, Michele Vonci, Yasmin L. Whyatt, Carys Williams, Kevin Mason, David Parker, Eric J. L. Mcinnes, Nicholas F. Chilton

Research output: Contribution to journal › Article › peer-review

Abstract

The hydration behaviour of coordination complexes is important for understanding their roles as bio-imaging agents. Determination of hydration is difficult, and various optical and NMR-based techniques have been used. Here we use EPR spectroscopy to unambiguously demonstrate that a t-butyl-pyridyl-functionalised ErIII DOTA derivative coordinates water, while its methylphosphinate analogue does not.

Original language	English
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/D3CC00601H
Publication status	Accepted/In press - 20 Mar 2023

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10.1039/D3CC00601HLicence: CC BY

EPSRC National Research Facility for Electron Paramagnetic Resonance
Collison, D. (Academic lead), Mcinnes, E. (Academic lead), Tuna, F. (Academic lead), Bowen, A. (Academic lead), Shanmugam, M. (Senior Technical Specialist), Brookfield, A. (Technical Specialist), Fleming, E. (Other) & Cliff, M. (Platform Lead)
FSE Research
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title = "Determination of molecular hydration in solution via changes in magnetic anisotropy",

abstract = "The hydration behaviour of coordination complexes is important for understanding their roles as bio-imaging agents. Determination of hydration is difficult, and various optical and NMR-based techniques have been used. Here we use EPR spectroscopy to unambiguously demonstrate that a t-butyl-pyridyl-functionalised ErIII DOTA derivative coordinates water, while its methylphosphinate analogue does not.",

author = "Giansiracusa, {Marcus J.} and Michele Vonci and Whyatt, {Yasmin L.} and Carys Williams and Kevin Mason and David Parker and Mcinnes, {Eric J. L.} and Chilton, {Nicholas F.}",

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AU - Giansiracusa, Marcus J.

AU - Vonci, Michele

AU - Whyatt, Yasmin L.

AU - Williams, Carys

AU - Mason, Kevin

AU - Parker, David

AU - Mcinnes, Eric J. L.

AU - Chilton, Nicholas F.

PY - 2023/3/20

Y1 - 2023/3/20

N2 - The hydration behaviour of coordination complexes is important for understanding their roles as bio-imaging agents. Determination of hydration is difficult, and various optical and NMR-based techniques have been used. Here we use EPR spectroscopy to unambiguously demonstrate that a t-butyl-pyridyl-functionalised ErIII DOTA derivative coordinates water, while its methylphosphinate analogue does not.

AB - The hydration behaviour of coordination complexes is important for understanding their roles as bio-imaging agents. Determination of hydration is difficult, and various optical and NMR-based techniques have been used. Here we use EPR spectroscopy to unambiguously demonstrate that a t-butyl-pyridyl-functionalised ErIII DOTA derivative coordinates water, while its methylphosphinate analogue does not.

U2 - 10.1039/D3CC00601H

DO - 10.1039/D3CC00601H

M3 - Article

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

Determination of molecular hydration in solution via changes in magnetic anisotropy

Abstract

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EPSRC National Research Facility for Electron Paramagnetic Resonance

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