Determination of the sensitivity and specificity of sibship calculations using AmpF/STR profiler plus

R. Gaytmenn, D. P. Hildebrand, D. Sweet, I. A. Pretty

Research output: Contribution to journalArticlepeer-review

Abstract

In circumstances where a known DNA reference sample from the deceased's belongings or biological parents is not available, more complex kinship analyses are possible. The purpose of the work reported here is to determine the sensitivity and specificity of the sibship analysis utilising multiple STR loci. Using all nine Profiler Plus loci, likelihood ratios for biologically-related siblings ranged from slightly less than 1 to over 45,000. When allelic dropout was mimicked, likelihood ratios ranged from less than 1 to over 1,000. Thus, the results of this study have a direct application to forensic laboratories faced with identifications involving sibling comparisons.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalInternational Journal of Legal Medicine
Volume116
Issue number3
DOIs
Publication statusPublished - 1 Dec 2002

Keywords

  • Human identification
  • Siblings
  • Sibship
  • STR loci

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