Deuterated carbohydrate probes as 'label-free' substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis

R. Lowery, M. I. Gibson, R. L. Thompson, E. Fullam

Research output: Contribution to journalLetterpeer-review

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Abstract

Understanding and probing small molecule uptake in cells is challenging, requiring sterically large chemical labels, or radioactive isotopes. Here, the uptake of deuterated sugars by Mycobacterium smegmatis, a non-pathogenic model of Mycobacterium tuberculosis, has been investigated using ion-beam (nuclear reaction) analysis demonstrating a new technique for label-free nutrient acquisition measurement.
Original languageEnglish
Pages (from-to)4838-4841
Number of pages4
JournalChemical Communications
Volume51
Issue number23
Early online date12 Feb 2015
DOIs
Publication statusPublished - 21 Mar 2015

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