Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

Graham J. Kemp; Fraser Birrell; Peter D. Clegg; Daniel J. Cuthbertson; Giuseppe De Vito; Jaap H. Van Dieën; Silvia Del Din; Richard Eastell; Patrick Garnero; Katarzyna Goljanek-Whysall; Matthias Hackl; Richard Hodgson; Malcolm J. Jackson; Sue Lord; Claudia Mazzà; Anne McArdle; Eugene V. McCloskey; Marco Narici; Mandy J. Peffers; Stefano Schiaffino; John C. Mathers

doi:10.1093/ageing/afy143

Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

Graham J. Kemp, Fraser Birrell, Peter D. Clegg, Daniel J. Cuthbertson, Giuseppe De Vito, Jaap H. Van Dieën, Silvia Del Din, Richard Eastell, Patrick Garnero, Katarzyna Goljanek-Whysall, Matthias Hackl, Richard Hodgson, Malcolm J. Jackson, Sue Lord, Claudia Mazzà, Anne McArdle, Eugene V. McCloskey, Marco Narici, Mandy J. Peffers, Stefano SchiaffinoJohn C. Mathers

Division of Informatics, Imaging & Data Sciences (L5)

Research output: Contribution to journal › Review article › peer-review

Abstract

The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA's objectives is to 'Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function'-in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during 'normal' ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: Biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.

Original language	English
Pages (from-to)	iv1-iv19
Journal	Age and Ageing
Volume	47
Early online date	7 Sept 2018
DOIs	https://doi.org/10.1093/ageing/afy143
Publication status	Published - Sept 2018

Keywords

biomarkers
bone
cartilage
healthy ageing
musculoskeletal ageing
skeletal muscle

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10.1093/ageing/afy143Licence: CC BY

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Kemp, G. J., Birrell, F., Clegg, P. D., Cuthbertson, D. J., De Vito, G., Van Dieën, J. H., Del Din, S., Eastell, R., Garnero, P., Goljanek-Whysall, K., Hackl, M., Hodgson, R., Jackson, M. J., Lord, S., Mazzà, C., McArdle, A., McCloskey, E. V., Narici, M., Peffers, M. J., ... Mathers, J. C. (2018). Developing a toolkit for the assessment and monitoring of musculoskeletal ageing. Age and Ageing, 47, iv1-iv19. https://doi.org/10.1093/ageing/afy143

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title = "Developing a toolkit for the assessment and monitoring of musculoskeletal ageing",

abstract = "The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA's objectives is to 'Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function'-in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during 'normal' ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: Biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.",

keywords = "biomarkers, bone, cartilage, healthy ageing, musculoskeletal ageing, skeletal muscle",

author = "Kemp, {Graham J.} and Fraser Birrell and Clegg, {Peter D.} and Cuthbertson, {Daniel J.} and {De Vito}, Giuseppe and {Van Die{\"e}n}, {Jaap H.} and {Del Din}, Silvia and Richard Eastell and Patrick Garnero and Katarzyna Goljanek-Whysall and Matthias Hackl and Richard Hodgson and Jackson, {Malcolm J.} and Sue Lord and Claudia Mazz{\`a} and Anne McArdle and McCloskey, {Eugene V.} and Marco Narici and Peffers, {Mandy J.} and Stefano Schiaffino and Mathers, {John C.}",

year = "2018",

month = sep,

doi = "10.1093/ageing/afy143",

language = "English",

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Kemp, GJ, Birrell, F, Clegg, PD, Cuthbertson, DJ, De Vito, G, Van Dieën, JH, Del Din, S, Eastell, R, Garnero, P, Goljanek-Whysall, K, Hackl, M, Hodgson, R, Jackson, MJ, Lord, S, Mazzà, C, McArdle, A, McCloskey, EV, Narici, M, Peffers, MJ, Schiaffino, S & Mathers, JC 2018, 'Developing a toolkit for the assessment and monitoring of musculoskeletal ageing', Age and Ageing, vol. 47, pp. iv1-iv19. https://doi.org/10.1093/ageing/afy143

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T1 - Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

AU - Kemp, Graham J.

AU - Birrell, Fraser

AU - Clegg, Peter D.

AU - Cuthbertson, Daniel J.

AU - De Vito, Giuseppe

AU - Van Dieën, Jaap H.

AU - Del Din, Silvia

AU - Eastell, Richard

AU - Garnero, Patrick

AU - Goljanek-Whysall, Katarzyna

AU - Hackl, Matthias

AU - Hodgson, Richard

AU - Jackson, Malcolm J.

AU - Lord, Sue

AU - Mazzà, Claudia

AU - McArdle, Anne

AU - McCloskey, Eugene V.

AU - Narici, Marco

AU - Peffers, Mandy J.

AU - Schiaffino, Stefano

AU - Mathers, John C.

PY - 2018/9

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N2 - The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA's objectives is to 'Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function'-in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during 'normal' ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: Biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.

AB - The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA's objectives is to 'Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function'-in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during 'normal' ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: Biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.

KW - biomarkers

KW - bone

KW - cartilage

KW - healthy ageing

KW - musculoskeletal ageing

KW - skeletal muscle

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U2 - 10.1093/ageing/afy143

DO - 10.1093/ageing/afy143

M3 - Review article

AN - SCOPUS:85054154795

SN - 0002-0729

VL - 47

SP - iv1-iv19

JO - Age and Ageing

JF - Age and Ageing

ER -

Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

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Keywords

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