Developing rat lung has a sided pacemaker region for morphogenesis-related airway peristalsis

Edwin C. Jesudason; Nicola P. Smith; Marilyn G. Connell; Dave G. Spiller; Mike R H White; Dave G. Fernig; Paul D. Losty

doi:10.1165/rcmb.2004-0304OC

Developing rat lung has a sided pacemaker region for morphogenesis-related airway peristalsis

Edwin C. Jesudason, Nicola P. Smith, Marilyn G. Connell, Dave G. Spiller, Mike R H White, Dave G. Fernig, Paul D. Losty

Research output: Contribution to journal › Article › peer-review

Abstract

Prenatal airways from diverse species are capable of spontaneous peristaltic contractions in each trimester. The function of this smooth muscle activity is unknown. We demonstrate that peristalsis of the embryonic airway originates from a sided pacemaker focus, is stimulated in a calcium-dependent fashion by the pulmonary morphogen fibroblast growth factor-10 (FCF-10), and appears coupled to lung growth. Airway peristalsis may be crucial for lung development (thereby providing a physiologic role for airway smooth muscle) and play a hitherto unanticipated role in reported transgenic mutant lung phenotypes.

Original language	English
Pages (from-to)	118-127
Number of pages	9
Journal	American Journal of Respiratory Cell and Molecular Biology
Volume	32
Issue number	2
DOIs	https://doi.org/10.1165/rcmb.2004-0304OC
Publication status	Published - Feb 2005

Keywords

Airway peristalsis
Lung branching morphogenesis
Pacemaker

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10.1165/rcmb.2004-0304OC

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title = "Developing rat lung has a sided pacemaker region for morphogenesis-related airway peristalsis",

abstract = "Prenatal airways from diverse species are capable of spontaneous peristaltic contractions in each trimester. The function of this smooth muscle activity is unknown. We demonstrate that peristalsis of the embryonic airway originates from a sided pacemaker focus, is stimulated in a calcium-dependent fashion by the pulmonary morphogen fibroblast growth factor-10 (FCF-10), and appears coupled to lung growth. Airway peristalsis may be crucial for lung development (thereby providing a physiologic role for airway smooth muscle) and play a hitherto unanticipated role in reported transgenic mutant lung phenotypes.",

keywords = "Airway peristalsis, Lung branching morphogenesis, Pacemaker",

author = "Jesudason, {Edwin C.} and Smith, {Nicola P.} and Connell, {Marilyn G.} and Spiller, {Dave G.} and White, {Mike R H} and Fernig, {Dave G.} and Losty, {Paul D.}",

year = "2005",

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publisher = "American Thoracic Society",

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T1 - Developing rat lung has a sided pacemaker region for morphogenesis-related airway peristalsis

AU - Jesudason, Edwin C.

AU - Smith, Nicola P.

AU - Connell, Marilyn G.

AU - Spiller, Dave G.

AU - White, Mike R H

AU - Fernig, Dave G.

AU - Losty, Paul D.

PY - 2005/2

Y1 - 2005/2

N2 - Prenatal airways from diverse species are capable of spontaneous peristaltic contractions in each trimester. The function of this smooth muscle activity is unknown. We demonstrate that peristalsis of the embryonic airway originates from a sided pacemaker focus, is stimulated in a calcium-dependent fashion by the pulmonary morphogen fibroblast growth factor-10 (FCF-10), and appears coupled to lung growth. Airway peristalsis may be crucial for lung development (thereby providing a physiologic role for airway smooth muscle) and play a hitherto unanticipated role in reported transgenic mutant lung phenotypes.

AB - Prenatal airways from diverse species are capable of spontaneous peristaltic contractions in each trimester. The function of this smooth muscle activity is unknown. We demonstrate that peristalsis of the embryonic airway originates from a sided pacemaker focus, is stimulated in a calcium-dependent fashion by the pulmonary morphogen fibroblast growth factor-10 (FCF-10), and appears coupled to lung growth. Airway peristalsis may be crucial for lung development (thereby providing a physiologic role for airway smooth muscle) and play a hitherto unanticipated role in reported transgenic mutant lung phenotypes.

KW - Airway peristalsis

KW - Lung branching morphogenesis

KW - Pacemaker

U2 - 10.1165/rcmb.2004-0304OC

DO - 10.1165/rcmb.2004-0304OC

M3 - Article

SN - 1044-1549

VL - 32

SP - 118

EP - 127

JO - American Journal of Respiratory Cell and Molecular Biology

JF - American Journal of Respiratory Cell and Molecular Biology

IS - 2

ER -

Developing rat lung has a sided pacemaker region for morphogenesis-related airway peristalsis

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Keywords

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