Developing trustworthy recommendations as part of an urgent response (1-2 weeks): a GRADE concept paper

GRADE Rapid Guidelines project group, Alexander Mathioudakis

Research output: Contribution to journalArticlepeer-review


Objective: To propose an approach for developing trustworthy recommendations as part of urgent responses (1-2 weeks) in the clinical, public health, and health systems fields. Study design and setting: We conducted a review of the literature, outlined a draft approach, refined the concept through iterative discussions, a workshop by the GRADE Rapid Guidelines project group, and obtained feedback from the larger GRADE working group.
Results: A request for developing recommendations within two weeks is the usual trigger for an urgent response. While the approach builds
on the general principles of trustworthy guideline development, we highlight the following steps: (1) assess the level of urgency; (2) assess feasibility; (3) set up the organizational logistics; (4) specify the question(s); (5) collect the information needed; (6) assess the adequacy of identified information; (7) develop the recommendations using one of four potential approaches: adopt existing recommendations; adapt existing recommendations; develop new recommendations using existing adequate systematic review; or develop new recommendations using expert panel input; and (8) consider an updating plan.
Conclusion: An urgent response for developing recommendations requires building a cohesive, skilled and highly motivated multidisciplinary team with the necessary clinical, scientific, and methodological expertise, adapting to shifting needs, complying with the principles of transparency and properly managing conflicts of interest.
Original languageEnglish
JournalJournal of Clinical Epidemiology
Early online date30 Sept 2020
Publication statusE-pub ahead of print - 30 Sept 2020


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