Development & Automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

Olivia Morris; J. Gregory; M. Kadirvel; Fiona Henderson; A. Blykers; Adam McMahon; Mark Taylor; David Allsop; Stuart Allan; J. Grigg; Herve Boutin; Christian Prenant

doi:10.1016/j.apradiso.2016.07.023

Development & Automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

Olivia Morris, J. Gregory, M. Kadirvel, Fiona Henderson, A. Blykers, Adam McMahon, Mark Taylor, David Allsop, Stuart Allan, J. Grigg, Herve Boutin, Christian Prenant

Research output: Contribution to journal › Article › peer-review

139 Downloads (Pure)

Abstract

2-[18F]-Fluoro-3-pyridinecarboxaldehyde ([18F]FPCA) is a novel, water-soluble prosthetic group. It’s radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer’s Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [18F]RI-OR2-TAT has been measured in Wistar rats.

Original language	English
Pages (from-to)	120–127
Number of pages	8
Journal	Applied Radiation and Isotopes
Volume	116
Early online date	27 Jul 2016
DOIs	https://doi.org/10.1016/j.apradiso.2016.07.023
Publication status	Published - 1 Oct 2016

Keywords

[F-18]F prosthetic group
PET
A beta peptide
Chemical ligation
Oxime bond

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.apradiso.2016.07.023Licence: CC BY

FPCA AD Applied Radiation FINAL 20160707Accepted author manuscript, 88.4 KB

Cite this

Morris, O., Gregory, J., Kadirvel, M., Henderson, F., Blykers, A., McMahon, A., Taylor, M., Allsop, D., Allan, S., Grigg, J., Boutin, H., & Prenant, C. (2016). Development & Automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide. Applied Radiation and Isotopes, 116, 120–127. https://doi.org/10.1016/j.apradiso.2016.07.023

@article{9ba0ed0a40384701a597b8e5e938c646,

title = "Development & Automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide",

abstract = "2-[18F]-Fluoro-3-pyridinecarboxaldehyde ([18F]FPCA) is a novel, water-soluble prosthetic group. It{\textquoteright}s radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer{\textquoteright}s Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [18F]RI-OR2-TAT has been measured in Wistar rats. ",

keywords = "[F-18]F prosthetic group, PET, A beta peptide, Chemical ligation, Oxime bond",

author = "Olivia Morris and J. Gregory and M. Kadirvel and Fiona Henderson and A. Blykers and Adam McMahon and Mark Taylor and David Allsop and Stuart Allan and J. Grigg and Herve Boutin and Christian Prenant",

year = "2016",

month = oct,

day = "1",

doi = "10.1016/j.apradiso.2016.07.023",

language = "English",

volume = "116",

pages = "120–127",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier BV",

}

Morris, O, Gregory, J, Kadirvel, M, Henderson, F, Blykers, A, McMahon, A, Taylor, M, Allsop, D, Allan, S, Grigg, J, Boutin, H & Prenant, C 2016, 'Development & Automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide', Applied Radiation and Isotopes, vol. 116, pp. 120–127. https://doi.org/10.1016/j.apradiso.2016.07.023

TY - JOUR

T1 - Development & Automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

AU - Morris, Olivia

AU - Gregory, J.

AU - Kadirvel, M.

AU - Henderson, Fiona

AU - Blykers, A.

AU - McMahon, Adam

AU - Taylor, Mark

AU - Allsop, David

AU - Allan, Stuart

AU - Grigg, J.

AU - Boutin, Herve

AU - Prenant, Christian

PY - 2016/10/1

Y1 - 2016/10/1

N2 - 2-[18F]-Fluoro-3-pyridinecarboxaldehyde ([18F]FPCA) is a novel, water-soluble prosthetic group. It’s radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer’s Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [18F]RI-OR2-TAT has been measured in Wistar rats.

AB - 2-[18F]-Fluoro-3-pyridinecarboxaldehyde ([18F]FPCA) is a novel, water-soluble prosthetic group. It’s radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer’s Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [18F]RI-OR2-TAT has been measured in Wistar rats.

KW - [F-18]F prosthetic group

KW - PET

KW - A beta peptide

KW - Chemical ligation

KW - Oxime bond

U2 - 10.1016/j.apradiso.2016.07.023

DO - 10.1016/j.apradiso.2016.07.023

M3 - Article

SN - 0969-8043

VL - 116

SP - 120

EP - 127

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Development & Automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this