Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Nikolaos Tsamandouras; G Dickinson; Y Guo; S Hall; Amin Rostami-Hochaghan; A Galetin; L Aarons

doi:10.1007/s11095-014-1581-2

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Nikolaos Tsamandouras, G Dickinson, Y Guo, S Hall, Amin Rostami-Hochaghan, A Galetin, L Aarons

Pharmacy

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	1573-904X
Pages (from-to)	1864-1883
Number of pages	19
Journal	Pharmaceutical Research
Volume	32
Issue number	6
DOIs	https://doi.org/10.1007/s11095-014-1581-2
Publication status	Published - 2 Dec 2014

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10.1007/s11095-014-1581-2

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Tsamandouras, N., Dickinson, G., Guo, Y., Hall, S., Rostami-Hochaghan, A., Galetin, A., & Aarons, L. (2014). Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach. Pharmaceutical Research, 32(6), 1864-1883. Article 1573-904X. https://doi.org/10.1007/s11095-014-1581-2

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Tsamandouras, N, Dickinson, G, Guo, Y, Hall, S, Rostami-Hochaghan, A , Galetin, A & Aarons, L 2014, 'Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach', Pharmaceutical Research, vol. 32, no. 6, 1573-904X, pp. 1864-1883. https://doi.org/10.1007/s11095-014-1581-2

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach. / Tsamandouras, Nikolaos; Dickinson, G; Guo, Y et al.
In: Pharmaceutical Research, Vol. 32, No. 6, 1573-904X, 02.12.2014, p. 1864-1883.

Research output: Contribution to journal › Article › peer-review

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AU - Tsamandouras, Nikolaos

AU - Dickinson, G

AU - Guo, Y

AU - Hall, S

AU - Rostami-Hochaghan, Amin

AU - Galetin, A

AU - Aarons, L

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