Development of a method for the preparation of zirconium-89 radiolabelled chitosan nanoparticles as an application for leukocyte trafficking with positron emission tomography.

Michael Fairclough, Beverley Ellis, Herve Boutin, Anthony Jones, Adam Mcmahon, Saba Alzabin, A Gennari, Christian Prenant

Research output: Contribution to journalArticlepeer-review

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Abstract

Positron Emission Tomography is an attractive imaging modality for monitoring the migration of cells to pathological tissue. We evaluated a new method for radiolabelling leukocytes with zirconium-89 (89Zr) using chitosan nanoparticles (CN, Z-average size 343 ± 210 nm and zeta potential +46 ± 4 mV) as the carrier. We propose that cell uptake of 89Zr-loaded CN occurred in a two-step process; cell membrane interaction with 89Zr-loaded CN was followed by a slower cell internalisation step.
Original languageEnglish
Pages (from-to)7-12
Number of pages5
JournalApplied Radiation and Isotopes
Volume130
Early online date6 Sept 2017
DOIs
Publication statusPublished - Dec 2017

Keywords

  • PET
  • Zr-89
  • Chitosan
  • Nanoparticles
  • leukocyte trafficking
  • inflammation imaging

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