Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

L Gaohua; S Neuhoff; TN Johnson; Amin Rostami-Hochaghan; M Jamei

doi:10.1016/j.dmpk.2016.03.005

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data

L Gaohua, S Neuhoff, TN Johnson, Amin Rostami-Hochaghan, M Jamei

Pharmacy

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	224-233
Journal	Drug Metabolism and Pharmacokinetics
Volume	31
DOIs	https://doi.org/10.1016/j.dmpk.2016.03.005
Publication status	Published - 4 Apr 2016

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10.1016/j.dmpk.2016.03.005

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Gaohua, L., Neuhoff, S., Johnson, TN., Rostami-Hochaghan, A., & Jamei, M. (2016). Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data. Drug Metabolism and Pharmacokinetics, 31, 224-233. https://doi.org/10.1016/j.dmpk.2016.03.005

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author = "L Gaohua and S Neuhoff and TN Johnson and Amin Rostami-Hochaghan and M Jamei",

year = "2016",

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doi = "10.1016/j.dmpk.2016.03.005",

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Gaohua, L, Neuhoff, S, Johnson, TN, Rostami-Hochaghan, A & Jamei, M 2016, 'Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data', Drug Metabolism and Pharmacokinetics, vol. 31, pp. 224-233. https://doi.org/10.1016/j.dmpk.2016.03.005

Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data. / Gaohua, L; Neuhoff, S; Johnson, TN et al.
In: Drug Metabolism and Pharmacokinetics, Vol. 31, 04.04.2016, p. 224-233.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

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AU - Gaohua, L

AU - Neuhoff, S

AU - Johnson, TN

AU - Rostami-Hochaghan, Amin

AU - Jamei, M

PY - 2016/4/4

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Gaohua L, Neuhoff S, Johnson TN, Rostami-Hochaghan A, Jamei M. Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data. Drug Metabolism and Pharmacokinetics. 2016 Apr 4;31:224-233. doi: 10.1016/j.dmpk.2016.03.005