Development of silk fibroin-derived nanofibrous drug delivery system in supercritical CO2

Maobin Xie; Yi Li; Zheng Zhao; Aizheng Chen; Jiashen Li; Zhi Li; Gang Li; Xiaofen Lin

doi:10.1016/j.matlet.2015.12.151

Development of silk fibroin-derived nanofibrous drug delivery system in supercritical CO2

Maobin Xie, Yi Li^*, Zheng Zhao, Aizheng Chen, Jiashen Li, Zhi Li, Gang Li, Xiaofen Lin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A silk fibroin (SF)-derived nanofibrous drug delivery system was fabricated by solution-enhanced dispersion via supercritical CO2 (SEDS) (20 MPa pressure, 8 mL/min flow rate, 35 °C temperature) in this study. Curcumin (CM) was used as a water-insoluble drug model. Nanofibrous structure with controllable fiber diameter (<100 nm) was obtained, and inter-molecular hydrogen bonds were formed between CM and SF; the crystallinity of the incorporated CM was remarkably decreased, which led to a significant enhancement in solubility of incorporated CM. In conclusion, SEDS could be developed to fabricate polymeric nanofibrous drug delivery system.

Original language	English
Pages (from-to)	175-178
Number of pages	4
Journal	Materials Letters
Volume	167
Early online date	29 Dec 2015
DOIs	https://doi.org/10.1016/j.matlet.2015.12.151
Publication status	Published - 29 Dec 2015

Keywords

Curcumin
Drug delivery system
Silk fibroin
Supercritical CO

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10.1016/j.matlet.2015.12.151

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title = "Development of silk fibroin-derived nanofibrous drug delivery system in supercritical CO2",

abstract = "A silk fibroin (SF)-derived nanofibrous drug delivery system was fabricated by solution-enhanced dispersion via supercritical CO2 (SEDS) (20 MPa pressure, 8 mL/min flow rate, 35 °C temperature) in this study. Curcumin (CM) was used as a water-insoluble drug model. Nanofibrous structure with controllable fiber diameter (<100 nm) was obtained, and inter-molecular hydrogen bonds were formed between CM and SF; the crystallinity of the incorporated CM was remarkably decreased, which led to a significant enhancement in solubility of incorporated CM. In conclusion, SEDS could be developed to fabricate polymeric nanofibrous drug delivery system.",

keywords = "Curcumin, Drug delivery system, Silk fibroin, Supercritical CO",

author = "Maobin Xie and Yi Li and Zheng Zhao and Aizheng Chen and Jiashen Li and Zhi Li and Gang Li and Xiaofen Lin",

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doi = "10.1016/j.matlet.2015.12.151",

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T1 - Development of silk fibroin-derived nanofibrous drug delivery system in supercritical CO2

AU - Xie, Maobin

AU - Li, Yi

AU - Zhao, Zheng

AU - Chen, Aizheng

AU - Li, Jiashen

AU - Li, Zhi

AU - Li, Gang

AU - Lin, Xiaofen

PY - 2015/12/29

Y1 - 2015/12/29

N2 - A silk fibroin (SF)-derived nanofibrous drug delivery system was fabricated by solution-enhanced dispersion via supercritical CO2 (SEDS) (20 MPa pressure, 8 mL/min flow rate, 35 °C temperature) in this study. Curcumin (CM) was used as a water-insoluble drug model. Nanofibrous structure with controllable fiber diameter (<100 nm) was obtained, and inter-molecular hydrogen bonds were formed between CM and SF; the crystallinity of the incorporated CM was remarkably decreased, which led to a significant enhancement in solubility of incorporated CM. In conclusion, SEDS could be developed to fabricate polymeric nanofibrous drug delivery system.

AB - A silk fibroin (SF)-derived nanofibrous drug delivery system was fabricated by solution-enhanced dispersion via supercritical CO2 (SEDS) (20 MPa pressure, 8 mL/min flow rate, 35 °C temperature) in this study. Curcumin (CM) was used as a water-insoluble drug model. Nanofibrous structure with controllable fiber diameter (<100 nm) was obtained, and inter-molecular hydrogen bonds were formed between CM and SF; the crystallinity of the incorporated CM was remarkably decreased, which led to a significant enhancement in solubility of incorporated CM. In conclusion, SEDS could be developed to fabricate polymeric nanofibrous drug delivery system.

KW - Curcumin

KW - Drug delivery system

KW - Silk fibroin

KW - Supercritical CO

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DO - 10.1016/j.matlet.2015.12.151

M3 - Article

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SN - 0167-577X

VL - 167

SP - 175

EP - 178

JO - Materials Letters

JF - Materials Letters

ER -

Development of silk fibroin-derived nanofibrous drug delivery system in supercritical CO2

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Keywords

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