Development of silk fibroin-derived nanofibrous drug delivery system in supercritical CO2

Maobin Xie, Yi Li, Zheng Zhao, Aizheng Chen, Jiashen Li, Zhi Li, Gang Li, Xiaofen Lin

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A silk fibroin (SF)-derived nanofibrous drug delivery system was fabricated by solution-enhanced dispersion via supercritical CO2 (SEDS) (20 MPa pressure, 8 mL/min flow rate, 35 °C temperature) in this study. Curcumin (CM) was used as a water-insoluble drug model. Nanofibrous structure with controllable fiber diameter (<100 nm) was obtained, and inter-molecular hydrogen bonds were formed between CM and SF; the crystallinity of the incorporated CM was remarkably decreased, which led to a significant enhancement in solubility of incorporated CM. In conclusion, SEDS could be developed to fabricate polymeric nanofibrous drug delivery system.
    Original languageEnglish
    Pages (from-to)175-178
    Number of pages4
    JournalMaterials Letters
    Volume167
    Early online date29 Dec 2015
    DOIs
    Publication statusPublished - 29 Dec 2015

    Keywords

    • Curcumin
    • Drug delivery system
    • Silk fibroin
    • Supercritical CO

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