TY - JOUR
T1 - Development of Water-Soluble Electrospun Fibers for the Oral Delivery of Cannabinoids
AU - Andriotis, Eleftherios G.
AU - Chachlioutaki, Konstantina
AU - Monou, Paraskevi Kyriaki
AU - Bouropoulos, Nikolaos
AU - Tzetzis, Dimitrios
AU - Barmpalexis, Panagiotis
AU - Chang, Ming Wei
AU - Ahmad, Zeeshan
AU - Fatouros, Dimitrios G.
N1 - Publisher Copyright:
© 2021, American Association of Pharmaceutical Scientists.
PY - 2021/1
Y1 - 2021/1
N2 - Cannabidiol (CBD) and cannabigerol (CBG) are two active pharmaceutical ingredients, derived from cannabis plant. In the present study, CBD and CBG were formulated with polyvinyl(pyrrolidone) (PVP) and Eudragit L-100, using electrohydrodynamic atomization (electrospinning). The produced fibers were smooth and uniform in shape, with average fiber diameters in the range of 700–900 nm for PVP fibers and 1–5 μm for Eudragit L-100 fibers. The encapsulation efficiency for both CB and CBG was high (over 90%) for all formulations tested. Both in vitro release and disintegration tests of the formulations in simulated gastric fluids (SGF) and simulated intestinal fluids (SIF) indicated the rapid disintegration and dissolution of the fibers and the subsequent rapid release of the drugs. The study concluded that the electrospinning process is a fast and efficient method to produce drug-loaded fibers suitable for the per os administration of cannabinoids.
AB - Cannabidiol (CBD) and cannabigerol (CBG) are two active pharmaceutical ingredients, derived from cannabis plant. In the present study, CBD and CBG were formulated with polyvinyl(pyrrolidone) (PVP) and Eudragit L-100, using electrohydrodynamic atomization (electrospinning). The produced fibers were smooth and uniform in shape, with average fiber diameters in the range of 700–900 nm for PVP fibers and 1–5 μm for Eudragit L-100 fibers. The encapsulation efficiency for both CB and CBG was high (over 90%) for all formulations tested. Both in vitro release and disintegration tests of the formulations in simulated gastric fluids (SGF) and simulated intestinal fluids (SIF) indicated the rapid disintegration and dissolution of the fibers and the subsequent rapid release of the drugs. The study concluded that the electrospinning process is a fast and efficient method to produce drug-loaded fibers suitable for the per os administration of cannabinoids.
KW - cannabidiol
KW - cannabigerol
KW - cannabinoids
KW - electrospinning
KW - nanofibers
KW - solid dispersion
UR - https://www.scopus.com/pages/publications/85098737872
U2 - 10.1208/s12249-020-01895-7
DO - 10.1208/s12249-020-01895-7
M3 - Article
C2 - 33400042
AN - SCOPUS:85098737872
SN - 1530-9932
VL - 22
JO - AAPS PharmSciTech
JF - AAPS PharmSciTech
IS - 1
M1 - 23
ER -