Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study

L C Chappell, S Duckworth, P T Seed, M Griffin, J Myers, L Mackillop, N Simpson, J Waugh, D Anumba, L C Kenny, C W Redman, A H Shennan

    Research output: Contribution to journalArticlepeer-review

    Abstract

    BACKGROUND: Hypertensive disorders of pregnancy are a major contributor to death and disability for pregnant women and their infants. The diagnosis of preeclampsia by using blood pressure and proteinuria is of limited use because they are tertiary, downstream features of the disease. Placental growth factor (PlGF) is an angiogenic factor, a secondary marker of associated placental dysfunction in preeclampsia, with known low plasma concentrations in the disease. METHODS AND RESULTS: In a prospective multicenter study, we studied the diagnostic accuracy of low plasma PlGF concentration (
    Original languageEnglish
    Pages (from-to)2121-31
    Number of pages2089
    JournalCirculation
    Volume128
    Issue number19
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Adult
    • Biological Markers/blood
    • Chemistry, Clinical/*standards
    • Female
    • Follow-Up Studies
    • Humans
    • Pre-Eclampsia/*blood/*diagnosis/epidemiology
    • Predictive Value of Tests
    • Pregnancy
    • Pregnancy Proteins/*blood
    • Prospective Studies
    • Reproducibility of Results
    • Risk Factors
    • Sensitivity and Specificity

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