Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study

L C Chappell; S Duckworth; P T Seed; M Griffin; J Myers; L Mackillop; N Simpson; J Waugh; D Anumba; L C Kenny; C W Redman; A H Shennan

doi:10.1161/CIRCULATIONAHA.113.003215

Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study

L C Chappell, S Duckworth, P T Seed, M Griffin, J Myers, L Mackillop, N Simpson, J Waugh, D Anumba, L C Kenny, C W Redman, A H Shennan

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Hypertensive disorders of pregnancy are a major contributor to death and disability for pregnant women and their infants. The diagnosis of preeclampsia by using blood pressure and proteinuria is of limited use because they are tertiary, downstream features of the disease. Placental growth factor (PlGF) is an angiogenic factor, a secondary marker of associated placental dysfunction in preeclampsia, with known low plasma concentrations in the disease. METHODS AND RESULTS: In a prospective multicenter study, we studied the diagnostic accuracy of low plasma PlGF concentration (

Original language	English
Pages (from-to)	2121-31
Number of pages	2089
Journal	Circulation
Volume	128
Issue number	19
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.113.003215
Publication status	Published - 2013

Keywords

Adult
Biological Markers/blood
Chemistry, Clinical/*standards
Female
Follow-Up Studies
Humans
Pre-Eclampsia/*blood/*diagnosis/epidemiology
Predictive Value of Tests
Pregnancy
Pregnancy Proteins/*blood
Prospective Studies
Reproducibility of Results
Risk Factors
Sensitivity and Specificity

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10.1161/CIRCULATIONAHA.113.003215

http://www.ncbi.nlm.nih.gov/pubmed/24190934

Placenta growth factor (PlGF) blood test for pre-eclampsia recommended by NICE then rolled out more widely by NHS England speeding up diagnosis and helping determine those most at risk
Myers, J. (Corresponding participant), Ormesher, L. (Participant), Johnstone, E. (Participant) & Duhig, K. (Participant)
Impact: Health and wellbeing, Economic

Cite this

Chappell, L. C., Duckworth, S., Seed, P. T., Griffin, M., Myers, J., Mackillop, L., Simpson, N., Waugh, J., Anumba, D., Kenny, L. C., Redman, C. W., & Shennan, A. H. (2013). Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study. Circulation, 128(19), 2121-31. https://doi.org/10.1161/CIRCULATIONAHA.113.003215

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abstract = "BACKGROUND: Hypertensive disorders of pregnancy are a major contributor to death and disability for pregnant women and their infants. The diagnosis of preeclampsia by using blood pressure and proteinuria is of limited use because they are tertiary, downstream features of the disease. Placental growth factor (PlGF) is an angiogenic factor, a secondary marker of associated placental dysfunction in preeclampsia, with known low plasma concentrations in the disease. METHODS AND RESULTS: In a prospective multicenter study, we studied the diagnostic accuracy of low plasma PlGF concentration (",

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author = "Chappell, {L C} and S Duckworth and Seed, {P T} and M Griffin and J Myers and L Mackillop and N Simpson and J Waugh and D Anumba and Kenny, {L C} and Redman, {C W} and Shennan, {A H}",

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AU - Chappell, L C

AU - Duckworth, S

AU - Seed, P T

AU - Griffin, M

AU - Myers, J

AU - Mackillop, L

AU - Simpson, N

AU - Waugh, J

AU - Anumba, D

AU - Kenny, L C

AU - Redman, C W

AU - Shennan, A H

N1 - Chappell, Lucy C Duckworth, Suzy Seed, Paul T Griffin, Melanie Myers, Jenny Mackillop, Lucy Simpson, Nigel Waugh, Jason Anumba, Dilly Kenny, Louise C Redman, Christopher W G Shennan, Andrew H Circulation. 2013 Nov 5;128(19):2121-31. doi: 10.1161/CIRCULATIONAHA.113.003215.

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N2 - BACKGROUND: Hypertensive disorders of pregnancy are a major contributor to death and disability for pregnant women and their infants. The diagnosis of preeclampsia by using blood pressure and proteinuria is of limited use because they are tertiary, downstream features of the disease. Placental growth factor (PlGF) is an angiogenic factor, a secondary marker of associated placental dysfunction in preeclampsia, with known low plasma concentrations in the disease. METHODS AND RESULTS: In a prospective multicenter study, we studied the diagnostic accuracy of low plasma PlGF concentration (

AB - BACKGROUND: Hypertensive disorders of pregnancy are a major contributor to death and disability for pregnant women and their infants. The diagnosis of preeclampsia by using blood pressure and proteinuria is of limited use because they are tertiary, downstream features of the disease. Placental growth factor (PlGF) is an angiogenic factor, a secondary marker of associated placental dysfunction in preeclampsia, with known low plasma concentrations in the disease. METHODS AND RESULTS: In a prospective multicenter study, we studied the diagnostic accuracy of low plasma PlGF concentration (

KW - Adult

KW - Biological Markers/blood

KW - Chemistry, Clinical/standards

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Pre-Eclampsia/blood/diagnosis/epidemiology

KW - Predictive Value of Tests

KW - Pregnancy

KW - Pregnancy Proteins/blood

KW - Prospective Studies

KW - Reproducibility of Results

KW - Risk Factors

KW - Sensitivity and Specificity

U2 - 10.1161/CIRCULATIONAHA.113.003215

DO - 10.1161/CIRCULATIONAHA.113.003215

M3 - Article

SN - 1524-4539

VL - 128

SP - 2121

EP - 2131

JO - Circulation

JF - Circulation

IS - 19

ER -

Diagnostic accuracy of placental growth factor in women with suspected preeclampsia: a prospective multicenter study

Abstract

Keywords

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Placenta growth factor (PlGF) blood test for pre-eclampsia recommended by NICE then rolled out more widely by NHS England speeding up diagnosis and helping determine those most at risk

Cite this