Diagnostic capacity for cutaneous fungal diseases in the African continent

Aida S Badiane; Lala S Ramarozatovo; Safiatou N Doumbo; Ameyo M Dorkenoo; Christine Mandengue; Cara M Dunaisk; Mamadou Ball; Mariem K Dia; Gilles S L Ngaya; Hassane H Mahamat; Hortense Kalombo; Alasana Bah; Zimania Cá; Jose C Langa; Ayni M Mohamed; Margaret Mokomane; Sarah A Ahmed; Fahafahantsoa Rapalanoro Rabenja; Roderick J Hay; Richard O S Penney; Emma Orefuwa; David W Denning

doi:10.1111/ijd.16751

Diagnostic capacity for cutaneous fungal diseases in the African continent

Aida S Badiane
, Lala S Ramarozatovo
, Safiatou N Doumbo
, Ameyo M Dorkenoo
, Christine Mandengue
, Cara M Dunaisk
, Mamadou Ball
, Mariem K Dia
, Gilles S L Ngaya
, Hassane H Mahamat
, Hortense Kalombo
, Alasana Bah
, Zimania Cá
, Jose C Langa
, Ayni M Mohamed
, Margaret Mokomane
, Sarah A Ahmed
, Fahafahantsoa Rapalanoro Rabenja
, Roderick J Hay
, Richard O S Penney

Emma Orefuwa, David W Denning

Division of Evolution, Infection and Genomics

University Cheikh Anta Diop of Dakar
Hôpital Universitaire JRB Antananarivo
Science University of Tokyo
Université de Lomé
Université des Montagnes
Namibia University of Science and Technology
Universite de Nouakchott
Hellenic Pasteur Institute
L'Association des Vétérinaires Africains (Rég. Afrique Centrale)
Ministère de la Santé Publique, Hygiène et Prévention, Democratic Republic of Congo (DRC)
London School of Hygiene & Tropical Medicine
Guinea Bissau National Health Center
Eduardo Mondlane University
National Public Health Reference Laboratory
University of Botswana
Radboud University Medical Center
King's College
Global Action Fund for Fungal Infections (GAFFI)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Cutaneous fungal infections are very common, especially in poorer communities and with intercurrent HIV infection. Determining the fungal pathogen in skin-related fungal neglected tropical diseases (NTDs) determines optimal therapy. We undertook a country survey across many African countries to determine the diagnostic capacity for skin fungal diseases.

METHODS: A detailed questionnaire was delivered to country contacts to collect data on availability, frequency, and location of testing for key diagnostic procedures and followed up with 2 rounds of validation by video call and by confirmation of individual country data confirmation by email.

RESULTS: Of 47 countries with data, seven (15%) and 21 (45%) do not offer skin biopsy in the public or private sector, respectively, but 22 (46%) countries do it regularly, mostly in university hospitals. Direct microscopy is often performed in 20 of 48 (42%) countries in the public sector and not done in 10 (21%). Fungal cultures are often performed in 21 of 48 (44%) countries in the public sector but not done in nine (20%) or 21 (44%) in either public or private facilities. Histopathological examination of tissue is frequently used in 19 of 48 (40%) countries but not in nine (20%) countries in the public sector. The cost of diagnostics to patients was a major limiting factor in usage.

CONCLUSION: Major improvements in the availability and use of diagnostic tests for skin, hair, and nail fungal disease are urgently needed across Africa.

Original language	English
Pages (from-to)	1131-1141
Number of pages	11
Journal	International Journal of Dermatology
Volume	62
Issue number	9
DOIs	https://doi.org/10.1111/ijd.16751
Publication status	Published - Sept 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Humans
Malaria
HIV Infections
Africa
Dermatomycoses/diagnosis
Private Sector

Access to Document

10.1111/ijd.16751

Cite this

Badiane, A. S., Ramarozatovo, L. S., Doumbo, S. N., Dorkenoo, A. M., Mandengue, C., Dunaisk, C. M., Ball, M., Dia, M. K., Ngaya, G. S. L., Mahamat, H. H., Kalombo, H., Bah, A., Cá, Z., Langa, J. C., Mohamed, A. M., Mokomane, M., Ahmed, S. A., Rapalanoro Rabenja, F., Hay, R. J., ... Denning, D. W. (2023). Diagnostic capacity for cutaneous fungal diseases in the African continent. International Journal of Dermatology, 62(9), 1131-1141. https://doi.org/10.1111/ijd.16751

@article{2c3722d491c341a6826a9e9e7c0d2a7d,

title = "Diagnostic capacity for cutaneous fungal diseases in the African continent",

abstract = "BACKGROUND: Cutaneous fungal infections are very common, especially in poorer communities and with intercurrent HIV infection. Determining the fungal pathogen in skin-related fungal neglected tropical diseases (NTDs) determines optimal therapy. We undertook a country survey across many African countries to determine the diagnostic capacity for skin fungal diseases.METHODS: A detailed questionnaire was delivered to country contacts to collect data on availability, frequency, and location of testing for key diagnostic procedures and followed up with 2 rounds of validation by video call and by confirmation of individual country data confirmation by email.RESULTS: Of 47 countries with data, seven (15\%) and 21 (45\%) do not offer skin biopsy in the public or private sector, respectively, but 22 (46\%) countries do it regularly, mostly in university hospitals. Direct microscopy is often performed in 20 of 48 (42\%) countries in the public sector and not done in 10 (21\%). Fungal cultures are often performed in 21 of 48 (44\%) countries in the public sector but not done in nine (20\%) or 21 (44\%) in either public or private facilities. Histopathological examination of tissue is frequently used in 19 of 48 (40\%) countries but not in nine (20\%) countries in the public sector. The cost of diagnostics to patients was a major limiting factor in usage.CONCLUSION: Major improvements in the availability and use of diagnostic tests for skin, hair, and nail fungal disease are urgently needed across Africa.",

keywords = "Humans, Malaria, HIV Infections, Africa, Dermatomycoses/diagnosis, Private Sector",

author = "Badiane, \{Aida S\} and Ramarozatovo, \{Lala S\} and Doumbo, \{Safiatou N\} and Dorkenoo, \{Ameyo M\} and Christine Mandengue and Dunaisk, \{Cara M\} and Mamadou Ball and Dia, \{Mariem K\} and Ngaya, \{Gilles S L\} and Mahamat, \{Hassane H\} and Hortense Kalombo and Alasana Bah and Zimania C{\'a} and Langa, \{Jose C\} and Mohamed, \{Ayni M\} and Margaret Mokomane and Ahmed, \{Sarah A\} and \{Rapalanoro Rabenja\}, Fahafahantsoa and Hay, \{Roderick J\} and Penney, \{Richard O S\} and Emma Orefuwa and Denning, \{David W\}",

note = "{\textcopyright} 2023 The Authors. International Journal of Dermatology published by Wiley Periodicals LLC on behalf of the International Society of Dermatology.",

year = "2023",

month = sep,

doi = "10.1111/ijd.16751",

language = "English",

volume = "62",

pages = "1131--1141",

journal = "International Journal of Dermatology",

issn = "0011-9059",

publisher = "John Wiley \& Sons Ltd",

number = "9",

}

Badiane, AS, Ramarozatovo, LS, Doumbo, SN, Dorkenoo, AM, Mandengue, C, Dunaisk, CM, Ball, M, Dia, MK, Ngaya, GSL, Mahamat, HH, Kalombo, H, Bah, A, Cá, Z, Langa, JC, Mohamed, AM, Mokomane, M, Ahmed, SA, Rapalanoro Rabenja, F, Hay, RJ, Penney, ROS, Orefuwa, E & Denning, DW 2023, 'Diagnostic capacity for cutaneous fungal diseases in the African continent', International Journal of Dermatology, vol. 62, no. 9, pp. 1131-1141. https://doi.org/10.1111/ijd.16751

TY - JOUR

T1 - Diagnostic capacity for cutaneous fungal diseases in the African continent

AU - Badiane, Aida S

AU - Ramarozatovo, Lala S

AU - Doumbo, Safiatou N

AU - Dorkenoo, Ameyo M

AU - Mandengue, Christine

AU - Dunaisk, Cara M

AU - Ball, Mamadou

AU - Dia, Mariem K

AU - Ngaya, Gilles S L

AU - Mahamat, Hassane H

AU - Kalombo, Hortense

AU - Bah, Alasana

AU - Cá, Zimania

AU - Langa, Jose C

AU - Mohamed, Ayni M

AU - Mokomane, Margaret

AU - Ahmed, Sarah A

AU - Rapalanoro Rabenja, Fahafahantsoa

AU - Hay, Roderick J

AU - Penney, Richard O S

AU - Orefuwa, Emma

AU - Denning, David W

PY - 2023/9

Y1 - 2023/9

N2 - BACKGROUND: Cutaneous fungal infections are very common, especially in poorer communities and with intercurrent HIV infection. Determining the fungal pathogen in skin-related fungal neglected tropical diseases (NTDs) determines optimal therapy. We undertook a country survey across many African countries to determine the diagnostic capacity for skin fungal diseases.METHODS: A detailed questionnaire was delivered to country contacts to collect data on availability, frequency, and location of testing for key diagnostic procedures and followed up with 2 rounds of validation by video call and by confirmation of individual country data confirmation by email.RESULTS: Of 47 countries with data, seven (15%) and 21 (45%) do not offer skin biopsy in the public or private sector, respectively, but 22 (46%) countries do it regularly, mostly in university hospitals. Direct microscopy is often performed in 20 of 48 (42%) countries in the public sector and not done in 10 (21%). Fungal cultures are often performed in 21 of 48 (44%) countries in the public sector but not done in nine (20%) or 21 (44%) in either public or private facilities. Histopathological examination of tissue is frequently used in 19 of 48 (40%) countries but not in nine (20%) countries in the public sector. The cost of diagnostics to patients was a major limiting factor in usage.CONCLUSION: Major improvements in the availability and use of diagnostic tests for skin, hair, and nail fungal disease are urgently needed across Africa.

AB - BACKGROUND: Cutaneous fungal infections are very common, especially in poorer communities and with intercurrent HIV infection. Determining the fungal pathogen in skin-related fungal neglected tropical diseases (NTDs) determines optimal therapy. We undertook a country survey across many African countries to determine the diagnostic capacity for skin fungal diseases.METHODS: A detailed questionnaire was delivered to country contacts to collect data on availability, frequency, and location of testing for key diagnostic procedures and followed up with 2 rounds of validation by video call and by confirmation of individual country data confirmation by email.RESULTS: Of 47 countries with data, seven (15%) and 21 (45%) do not offer skin biopsy in the public or private sector, respectively, but 22 (46%) countries do it regularly, mostly in university hospitals. Direct microscopy is often performed in 20 of 48 (42%) countries in the public sector and not done in 10 (21%). Fungal cultures are often performed in 21 of 48 (44%) countries in the public sector but not done in nine (20%) or 21 (44%) in either public or private facilities. Histopathological examination of tissue is frequently used in 19 of 48 (40%) countries but not in nine (20%) countries in the public sector. The cost of diagnostics to patients was a major limiting factor in usage.CONCLUSION: Major improvements in the availability and use of diagnostic tests for skin, hair, and nail fungal disease are urgently needed across Africa.

KW - Humans

KW - Malaria

KW - HIV Infections

KW - Africa

KW - Dermatomycoses/diagnosis

KW - Private Sector

U2 - 10.1111/ijd.16751

DO - 10.1111/ijd.16751

M3 - Article

C2 - 37340531

SN - 0011-9059

VL - 62

SP - 1131

EP - 1141

JO - International Journal of Dermatology

JF - International Journal of Dermatology

IS - 9

ER -

Diagnostic capacity for cutaneous fungal diseases in the African continent

Abstract

UN SDGs

Keywords

Access to Document

Fingerprint

Cite this