Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy

R W Adams; Liam Byrne; Peter Kiraly; Mohammadali Foroozandeh; Liladhar Paudel; Mathias Nilsson; Jonathan Clayden; Gareth Morris

doi:10.1039/c3cc49659g

Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy

R W Adams, Liam Byrne, Peter Kiraly, Mohammadali Foroozandeh, Liladhar Paudel, Mathias Nilsson, Jonathan Clayden, Gareth Morris

Research output: Contribution to journal › Article › peer-review

Abstract

An NMR method is reported that allows diastereomeric ratios to be determined even in crowded spectra or where chemical shift differences are small compared to multiplet widths. Band-selective pure shift NMR collapses multiplets to singlets, greatly improving spectral resolution while largely retaining, or even enhancing, signal-to-noise ratio. © 2014 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	2512-2514
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	19
DOIs	https://doi.org/10.1039/c3cc49659g
Publication status	Published - 7 Mar 2014

Keywords

magnetic-resonance
spectra
resolution
h-1-nmr
sample
epimer
trains
bird
dosy

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10.1039/c3cc49659g

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abstract = "An NMR method is reported that allows diastereomeric ratios to be determined even in crowded spectra or where chemical shift differences are small compared to multiplet widths. Band-selective pure shift NMR collapses multiplets to singlets, greatly improving spectral resolution while largely retaining, or even enhancing, signal-to-noise ratio. {\textcopyright} 2014 The Royal Society of Chemistry.",

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AU - Adams, R W

AU - Byrne, Liam

AU - Kiraly, Peter

AU - Foroozandeh, Mohammadali

AU - Paudel, Liladhar

AU - Nilsson, Mathias

AU - Clayden, Jonathan

AU - Morris, Gareth

N1 - Aa5yc Times Cited:7 Cited References Count:24

PY - 2014/3/7

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N2 - An NMR method is reported that allows diastereomeric ratios to be determined even in crowded spectra or where chemical shift differences are small compared to multiplet widths. Band-selective pure shift NMR collapses multiplets to singlets, greatly improving spectral resolution while largely retaining, or even enhancing, signal-to-noise ratio. © 2014 The Royal Society of Chemistry.

AB - An NMR method is reported that allows diastereomeric ratios to be determined even in crowded spectra or where chemical shift differences are small compared to multiplet widths. Band-selective pure shift NMR collapses multiplets to singlets, greatly improving spectral resolution while largely retaining, or even enhancing, signal-to-noise ratio. © 2014 The Royal Society of Chemistry.

KW - magnetic-resonance

KW - spectra

KW - resolution

KW - h-1-nmr

KW - sample

KW - epimer

KW - trains

KW - bird

KW - dosy

U2 - 10.1039/c3cc49659g

DO - 10.1039/c3cc49659g

M3 - Article

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SP - 2512

EP - 2514

JO - Chemical Communications

JF - Chemical Communications

IS - 19

ER -

Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy

Abstract

Keywords

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