Dietary intake and the insulin-like growth factor system: effects of migration in two related populations in India and Britain with markedly different dietary intake

A H Heald; R Sharma; S G Anderson; A Vyas; K Siddals; J Patel; D Bhatnagar; D Prabharkaran; A Rudenski; E Hughes; P Durrington; J M Gibson; J K Cruickshank

doi:10.1079/PHN2005729

Dietary intake and the insulin-like growth factor system: effects of migration in two related populations in India and Britain with markedly different dietary intake

A H Heald, R Sharma, S G Anderson, A Vyas, K Siddals, J Patel, D Bhatnagar, D Prabharkaran, A Rudenski, E Hughes, P Durrington, J M Gibson, J K Cruickshank

Manchester Institute of Education

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: The insulin-like growth factor (IGF) system is implicated in the pathogenesis of diabetes and cardiovascular disease.

OBJECTIVE: We report the effects of total energy intake on the IGF system in two populations with markedly different dietary macronutrient intake and cardiovascular event rate.

DESIGN, SUBJECTS AND SETTING: Dietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell, UK (n=205) compared with people still resident in the same villages of origin in India (n=246). Fasting IGF-I, IGF-binding protein (IGFBP)-1 and IGFBP-3, insulin and glucose (0 and 2-hour) were measured.

RESULTS: Total energy and total fat intake were higher in UK migrants, as were IGFBP-3 and IGF-I (mean (95% confidence interval): 145.9 (138.1-153.6) vs. 100.9 (94.6-107.3) ng ml(-1); F=76.6, P<0.001). IGFBP-1 was lower in UK migrants (29.5 (25.9-33.0) vs. 56.5 (50.6-62.5) microg l(-1); F=48.4, P<0.001). At both sites, IGF-I correlated positively with total energy (Spearman's rho=0.45, P<0.001) and total fat (rho=0.44, P<0.001) as did IGFBP-3 with total energy (rho=0.21, P<0.05) and fat (rho=0.26, P<0.001). Conversely, in Indian Gujaratis, IGFBP-1 fell with increasing total energy (rho=-0.27, P<0.001) and fat intake (rho=-0.26, P<0.01) but not in UK Gujaratis. Multiple linear regression modelling showed that increasing quartiles of fat intake were associated with higher IGF-I (beta=0.42, P=0.007) independent of age, body mass index, plasma insulin, fatty acids and 2-hour glucose.

CONCLUSION: In these genetically similar groups, migration to the UK and adoption of a different diet is associated with marked changes in the IGF system, suggesting that environmental factors profoundly modulate serum concentrations and actions of IGFs.

Original language	English
Pages (from-to)	620-7
Number of pages	8
Journal	Public Health Nutrition
Volume	8
Issue number	6
DOIs	https://doi.org/10.1079/PHN2005729
Publication status	Published - Sept 2005

Keywords

Blood Glucose
Cardiovascular Diseases
Diet
Dietary Carbohydrates
Dietary Fats
Dietary Proteins
Emigration and Immigration
Energy Intake
Female
Great Britain
Humans
India
Insulin
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Male
Middle Aged
Ethnicity
Migration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1079/PHN2005729

Cite this

Heald, A. H., Sharma, R., Anderson, S. G., Vyas, A., Siddals, K., Patel, J., Bhatnagar, D., Prabharkaran, D., Rudenski, A., Hughes, E., Durrington, P., Gibson, J. M., & Cruickshank, J. K. (2005). Dietary intake and the insulin-like growth factor system: effects of migration in two related populations in India and Britain with markedly different dietary intake. Public Health Nutrition, 8(6), 620-7. https://doi.org/10.1079/PHN2005729

@article{3715c270eae14ab4a2a8a9ed537be4a9,

title = "Dietary intake and the insulin-like growth factor system: effects of migration in two related populations in India and Britain with markedly different dietary intake",

abstract = "BACKGROUND: The insulin-like growth factor (IGF) system is implicated in the pathogenesis of diabetes and cardiovascular disease.OBJECTIVE: We report the effects of total energy intake on the IGF system in two populations with markedly different dietary macronutrient intake and cardiovascular event rate.DESIGN, SUBJECTS AND SETTING: Dietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell, UK (n=205) compared with people still resident in the same villages of origin in India (n=246). Fasting IGF-I, IGF-binding protein (IGFBP)-1 and IGFBP-3, insulin and glucose (0 and 2-hour) were measured.RESULTS: Total energy and total fat intake were higher in UK migrants, as were IGFBP-3 and IGF-I (mean (95% confidence interval): 145.9 (138.1-153.6) vs. 100.9 (94.6-107.3) ng ml(-1); F=76.6, P<0.001). IGFBP-1 was lower in UK migrants (29.5 (25.9-33.0) vs. 56.5 (50.6-62.5) microg l(-1); F=48.4, P<0.001). At both sites, IGF-I correlated positively with total energy (Spearman's rho=0.45, P<0.001) and total fat (rho=0.44, P<0.001) as did IGFBP-3 with total energy (rho=0.21, P<0.05) and fat (rho=0.26, P<0.001). Conversely, in Indian Gujaratis, IGFBP-1 fell with increasing total energy (rho=-0.27, P<0.001) and fat intake (rho=-0.26, P<0.01) but not in UK Gujaratis. Multiple linear regression modelling showed that increasing quartiles of fat intake were associated with higher IGF-I (beta=0.42, P=0.007) independent of age, body mass index, plasma insulin, fatty acids and 2-hour glucose.CONCLUSION: In these genetically similar groups, migration to the UK and adoption of a different diet is associated with marked changes in the IGF system, suggesting that environmental factors profoundly modulate serum concentrations and actions of IGFs.",

keywords = "Blood Glucose, Cardiovascular Diseases, Diet, Dietary Carbohydrates, Dietary Fats, Dietary Proteins, Emigration and Immigration, Energy Intake, Female, Great Britain, Humans, India, Insulin, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Male, Middle Aged, Ethnicity, Migration",

author = "Heald, {A H} and R Sharma and Anderson, {S G} and A Vyas and K Siddals and J Patel and D Bhatnagar and D Prabharkaran and A Rudenski and E Hughes and P Durrington and Gibson, {J M} and Cruickshank, {J K}",

year = "2005",

month = sep,

doi = "10.1079/PHN2005729",

language = "English",

volume = "8",

pages = "620--7",

journal = "Public Health Nutrition",

issn = "1368-9800",

publisher = "Cambridge University Press",

number = "6",

}

Heald, AH, Sharma, R, Anderson, SG, Vyas, A, Siddals, K, Patel, J, Bhatnagar, D, Prabharkaran, D, Rudenski, A, Hughes, E, Durrington, P, Gibson, JM & Cruickshank, JK 2005, 'Dietary intake and the insulin-like growth factor system: effects of migration in two related populations in India and Britain with markedly different dietary intake', Public Health Nutrition, vol. 8, no. 6, pp. 620-7. https://doi.org/10.1079/PHN2005729

TY - JOUR

T1 - Dietary intake and the insulin-like growth factor system

T2 - effects of migration in two related populations in India and Britain with markedly different dietary intake

AU - Heald, A H

AU - Sharma, R

AU - Anderson, S G

AU - Vyas, A

AU - Siddals, K

AU - Patel, J

AU - Bhatnagar, D

AU - Prabharkaran, D

AU - Rudenski, A

AU - Hughes, E

AU - Durrington, P

AU - Gibson, J M

AU - Cruickshank, J K

PY - 2005/9

Y1 - 2005/9

N2 - BACKGROUND: The insulin-like growth factor (IGF) system is implicated in the pathogenesis of diabetes and cardiovascular disease.OBJECTIVE: We report the effects of total energy intake on the IGF system in two populations with markedly different dietary macronutrient intake and cardiovascular event rate.DESIGN, SUBJECTS AND SETTING: Dietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell, UK (n=205) compared with people still resident in the same villages of origin in India (n=246). Fasting IGF-I, IGF-binding protein (IGFBP)-1 and IGFBP-3, insulin and glucose (0 and 2-hour) were measured.RESULTS: Total energy and total fat intake were higher in UK migrants, as were IGFBP-3 and IGF-I (mean (95% confidence interval): 145.9 (138.1-153.6) vs. 100.9 (94.6-107.3) ng ml(-1); F=76.6, P<0.001). IGFBP-1 was lower in UK migrants (29.5 (25.9-33.0) vs. 56.5 (50.6-62.5) microg l(-1); F=48.4, P<0.001). At both sites, IGF-I correlated positively with total energy (Spearman's rho=0.45, P<0.001) and total fat (rho=0.44, P<0.001) as did IGFBP-3 with total energy (rho=0.21, P<0.05) and fat (rho=0.26, P<0.001). Conversely, in Indian Gujaratis, IGFBP-1 fell with increasing total energy (rho=-0.27, P<0.001) and fat intake (rho=-0.26, P<0.01) but not in UK Gujaratis. Multiple linear regression modelling showed that increasing quartiles of fat intake were associated with higher IGF-I (beta=0.42, P=0.007) independent of age, body mass index, plasma insulin, fatty acids and 2-hour glucose.CONCLUSION: In these genetically similar groups, migration to the UK and adoption of a different diet is associated with marked changes in the IGF system, suggesting that environmental factors profoundly modulate serum concentrations and actions of IGFs.

AB - BACKGROUND: The insulin-like growth factor (IGF) system is implicated in the pathogenesis of diabetes and cardiovascular disease.OBJECTIVE: We report the effects of total energy intake on the IGF system in two populations with markedly different dietary macronutrient intake and cardiovascular event rate.DESIGN, SUBJECTS AND SETTING: Dietary macronutrient intake was measured in a specific Gujarati migrant community in Sandwell, UK (n=205) compared with people still resident in the same villages of origin in India (n=246). Fasting IGF-I, IGF-binding protein (IGFBP)-1 and IGFBP-3, insulin and glucose (0 and 2-hour) were measured.RESULTS: Total energy and total fat intake were higher in UK migrants, as were IGFBP-3 and IGF-I (mean (95% confidence interval): 145.9 (138.1-153.6) vs. 100.9 (94.6-107.3) ng ml(-1); F=76.6, P<0.001). IGFBP-1 was lower in UK migrants (29.5 (25.9-33.0) vs. 56.5 (50.6-62.5) microg l(-1); F=48.4, P<0.001). At both sites, IGF-I correlated positively with total energy (Spearman's rho=0.45, P<0.001) and total fat (rho=0.44, P<0.001) as did IGFBP-3 with total energy (rho=0.21, P<0.05) and fat (rho=0.26, P<0.001). Conversely, in Indian Gujaratis, IGFBP-1 fell with increasing total energy (rho=-0.27, P<0.001) and fat intake (rho=-0.26, P<0.01) but not in UK Gujaratis. Multiple linear regression modelling showed that increasing quartiles of fat intake were associated with higher IGF-I (beta=0.42, P=0.007) independent of age, body mass index, plasma insulin, fatty acids and 2-hour glucose.CONCLUSION: In these genetically similar groups, migration to the UK and adoption of a different diet is associated with marked changes in the IGF system, suggesting that environmental factors profoundly modulate serum concentrations and actions of IGFs.

KW - Blood Glucose

KW - Cardiovascular Diseases

KW - Diet

KW - Dietary Carbohydrates

KW - Dietary Fats

KW - Dietary Proteins

KW - Emigration and Immigration

KW - Energy Intake

KW - Female

KW - Great Britain

KW - Humans

KW - India

KW - Insulin

KW - Insulin-Like Growth Factor Binding Protein 1

KW - Insulin-Like Growth Factor Binding Protein 3

KW - Insulin-Like Growth Factor I

KW - Male

KW - Middle Aged

KW - Ethnicity

KW - Migration

U2 - 10.1079/PHN2005729

DO - 10.1079/PHN2005729

M3 - Article

C2 - 16236191

SN - 1368-9800

VL - 8

SP - 620

EP - 627

JO - Public Health Nutrition

JF - Public Health Nutrition

IS - 6

ER -

Dietary intake and the insulin-like growth factor system: effects of migration in two related populations in India and Britain with markedly different dietary intake

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this