DIF signalling and cell fate

Robert R. Kay; Paul Flatman; Christopher R L Thompson

doi:10.1006/scdb.1999.0341

DIF signalling and cell fate

Robert R. Kay, Paul Flatman, Christopher R L Thompson

Research output: Contribution to journal › Article › peer-review

Abstract

The DIFs are a family of secreted chlorinated molecules that control cell fate during development ofDictyostelium cells in culture and probably during normal development too. They induce stalk cell differentiation and suppress spore cell formation. The biosynthetic and inactivation pathways of DIF-1 (the major bioactivity) have been worked out. DIF-1 is probably synthesised in prespore cells and inactivated in prestalk cells, by dechlorination. Thus, each cell type tends to alter DIF-1 level so as to favour differentiation of the other cell type. This relationship leads to a model for cell-type proportioning during normal development. © 1999 Academic Press.

Original language	English
Pages (from-to)	577-585
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1006/scdb.1999.0341
Publication status	Published - Dec 1999

Keywords

Dictyostelium, DIF, DIF-dechlorinase, DIF-1 biosynthesis, proportioning model

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10.1006/scdb.1999.0341

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title = "DIF signalling and cell fate",

abstract = "The DIFs are a family of secreted chlorinated molecules that control cell fate during development ofDictyostelium cells in culture and probably during normal development too. They induce stalk cell differentiation and suppress spore cell formation. The biosynthetic and inactivation pathways of DIF-1 (the major bioactivity) have been worked out. DIF-1 is probably synthesised in prespore cells and inactivated in prestalk cells, by dechlorination. Thus, each cell type tends to alter DIF-1 level so as to favour differentiation of the other cell type. This relationship leads to a model for cell-type proportioning during normal development. {\textcopyright} 1999 Academic Press.",

keywords = "Dictyostelium, DIF, DIF-dechlorinase, DIF-1 biosynthesis, proportioning model",

author = "Kay, {Robert R.} and Paul Flatman and Thompson, {Christopher R L}",

year = "1999",

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AU - Kay, Robert R.

AU - Flatman, Paul

AU - Thompson, Christopher R L

PY - 1999/12

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AB - The DIFs are a family of secreted chlorinated molecules that control cell fate during development ofDictyostelium cells in culture and probably during normal development too. They induce stalk cell differentiation and suppress spore cell formation. The biosynthetic and inactivation pathways of DIF-1 (the major bioactivity) have been worked out. DIF-1 is probably synthesised in prespore cells and inactivated in prestalk cells, by dechlorination. Thus, each cell type tends to alter DIF-1 level so as to favour differentiation of the other cell type. This relationship leads to a model for cell-type proportioning during normal development. © 1999 Academic Press.

KW - Dictyostelium, DIF, DIF-dechlorinase, DIF-1 biosynthesis, proportioning model

U2 - 10.1006/scdb.1999.0341

DO - 10.1006/scdb.1999.0341

M3 - Article

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SN - 1084-9521

VL - 10

SP - 577

EP - 585

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 6

ER -

DIF signalling and cell fate

Abstract

Keywords

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