Differences in the cleavage of DNA by bleomycin under light (300-350 nm) and dark conditions

Kenneth T. Douglas; N. Thakrar; Steven J. Minter; R. Wayne Davies; Claude Scazzochio

doi:10.1016/0304-3835(82)90016-7

Differences in the cleavage of DNA by bleomycin under light (300-350 nm) and dark conditions

Kenneth T. Douglas^*, N. Thakrar, Steven J. Minter, R. Wayne Davies, Claude Scazzochio

^*Corresponding author for this work

Pharmacy

Research output: Contribution to journal › Letter › peer-review

Abstract

Incubation of supercoiled plasmid DNA (both pBR 322 and pPLC-28) with increasing concentrations of bleomycin in the presence and absence of light (300-350 nm) showed extensive conversion of supercoiled to linear DNA which occurred at much lower levels of bleomycin (BLM) in the light than in the dark. Preliminary results indicate that superoxide dismutase (SOD) may offer DNA more protection against bleomycin in the dark than in the light conditions.

Original language	English
Pages (from-to)	339-345
Number of pages	7
Journal	Cancer Letters
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(82)90016-7
Publication status	Published - Sept 1982

Access to Document

10.1016/0304-3835(82)90016-7

Cite this

@article{faa3ca903b8c4d3e852b3e87a83f6096,

title = "Differences in the cleavage of DNA by bleomycin under light (300-350 nm) and dark conditions",

abstract = "Incubation of supercoiled plasmid DNA (both pBR 322 and pPLC-28) with increasing concentrations of bleomycin in the presence and absence of light (300-350 nm) showed extensive conversion of supercoiled to linear DNA which occurred at much lower levels of bleomycin (BLM) in the light than in the dark. Preliminary results indicate that superoxide dismutase (SOD) may offer DNA more protection against bleomycin in the dark than in the light conditions.",

author = "Douglas, {Kenneth T.} and N. Thakrar and Minter, {Steven J.} and Davies, {R. Wayne} and Claude Scazzochio",

year = "1982",

month = sep,

doi = "10.1016/0304-3835(82)90016-7",

language = "English",

volume = "16",

pages = "339--345",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Differences in the cleavage of DNA by bleomycin under light (300-350 nm) and dark conditions

AU - Douglas, Kenneth T.

AU - Thakrar, N.

AU - Minter, Steven J.

AU - Davies, R. Wayne

AU - Scazzochio, Claude

PY - 1982/9

Y1 - 1982/9

N2 - Incubation of supercoiled plasmid DNA (both pBR 322 and pPLC-28) with increasing concentrations of bleomycin in the presence and absence of light (300-350 nm) showed extensive conversion of supercoiled to linear DNA which occurred at much lower levels of bleomycin (BLM) in the light than in the dark. Preliminary results indicate that superoxide dismutase (SOD) may offer DNA more protection against bleomycin in the dark than in the light conditions.

AB - Incubation of supercoiled plasmid DNA (both pBR 322 and pPLC-28) with increasing concentrations of bleomycin in the presence and absence of light (300-350 nm) showed extensive conversion of supercoiled to linear DNA which occurred at much lower levels of bleomycin (BLM) in the light than in the dark. Preliminary results indicate that superoxide dismutase (SOD) may offer DNA more protection against bleomycin in the dark than in the light conditions.

UR - http://www.scopus.com/inward/record.url?scp=0019958934&partnerID=8YFLogxK

U2 - 10.1016/0304-3835(82)90016-7

DO - 10.1016/0304-3835(82)90016-7

M3 - Letter

C2 - 6185218

AN - SCOPUS:0019958934

SN - 0304-3835

VL - 16

SP - 339

EP - 345

JO - Cancer Letters

JF - Cancer Letters

IS - 3

ER -

Differences in the cleavage of DNA by bleomycin under light (300-350 nm) and dark conditions

Abstract

Access to Document

Other files and links

Fingerprint

Cite this