Differential modulation of L-type Ca2+ current by SR Ca2+ release at the T-tubules and surface membrane of rat ventricular myocytes.

Fabien Brette; Laurent Sallé; Clive H. Orchard

doi:10.1161/01.RES.0000135547.53927.F6

Differential modulation of L-type Ca2+ current by SR Ca2+ release at the T-tubules and surface membrane of rat ventricular myocytes.

Fabien Brette, Laurent Sallé, Clive H. Orchard

Research output: Contribution to journal › Article › peer-review

Abstract

We have characterized modulation of ICa by Ca2+ at the t-tubules (ie, in control cells) and surface sarcolemma (ie, in detubulated cells) of cardiac ventricular myocytes, using the whole-cell patch clamp technique to record ICa. ICa inactivation was significantly slower in detubulated cells than in control cells (27.1+/-7.8 ms, n=22, versus 16.4+/-7.9 ms, n=22; P

Original language	English
Pages (from-to)	e1-7
Journal	Circulation research
Volume	95
Issue number	1
DOIs	https://doi.org/10.1161/01.RES.0000135547.53927.F6
Publication status	Published - 9 Jul 2004

Access to Document

10.1161/01.RES.0000135547.53927.F6

Cite this

@article{3f63b93375784fd0a946ba063fd07536,

title = "Differential modulation of L-type Ca2+ current by SR Ca2+ release at the T-tubules and surface membrane of rat ventricular myocytes.",

abstract = "We have characterized modulation of ICa by Ca2+ at the t-tubules (ie, in control cells) and surface sarcolemma (ie, in detubulated cells) of cardiac ventricular myocytes, using the whole-cell patch clamp technique to record ICa. ICa inactivation was significantly slower in detubulated cells than in control cells (27.1+/-7.8 ms, n=22, versus 16.4+/-7.9 ms, n=22; P",

author = "Fabien Brette and Laurent Sall{\'e} and Orchard, {Clive H.}",

year = "2004",

month = jul,

day = "9",

doi = "10.1161/01.RES.0000135547.53927.F6",

language = "English",

volume = "95",

pages = "e1--7",

journal = "Circulation research",

issn = "1524-4571",

publisher = "Lippincott Williams & Wilkins",

number = "1",

}

TY - JOUR

T1 - Differential modulation of L-type Ca2+ current by SR Ca2+ release at the T-tubules and surface membrane of rat ventricular myocytes.

AU - Brette, Fabien

AU - Sallé, Laurent

AU - Orchard, Clive H.

PY - 2004/7/9

Y1 - 2004/7/9

N2 - We have characterized modulation of ICa by Ca2+ at the t-tubules (ie, in control cells) and surface sarcolemma (ie, in detubulated cells) of cardiac ventricular myocytes, using the whole-cell patch clamp technique to record ICa. ICa inactivation was significantly slower in detubulated cells than in control cells (27.1+/-7.8 ms, n=22, versus 16.4+/-7.9 ms, n=22; P

AB - We have characterized modulation of ICa by Ca2+ at the t-tubules (ie, in control cells) and surface sarcolemma (ie, in detubulated cells) of cardiac ventricular myocytes, using the whole-cell patch clamp technique to record ICa. ICa inactivation was significantly slower in detubulated cells than in control cells (27.1+/-7.8 ms, n=22, versus 16.4+/-7.9 ms, n=22; P

U2 - 10.1161/01.RES.0000135547.53927.F6

DO - 10.1161/01.RES.0000135547.53927.F6

M3 - Article

SN - 1524-4571

VL - 95

SP - e1-7

JO - Circulation research

JF - Circulation research

IS - 1

ER -

Differential modulation of L-type Ca2+ current by SR Ca2+ release at the T-tubules and surface membrane of rat ventricular myocytes.

Abstract

Access to Document

Fingerprint

Cite this