Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke

David J. Werring; Ahmed T. Toosy; Christopher A. Clark; Geoffrey J M Parker; Gareth J. Barker; David H. Miller; Alan J. Thompson

doi:10.1136/jnnp.69.2.269

Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke

David J. Werring, Ahmed T. Toosy, Christopher A. Clark, Geoffrey J M Parker, Gareth J. Barker, David H. Miller, Alan J. Thompson

Research output: Contribution to journal › Article › peer-review

Abstract

Diffusion tensor imaging (DTI) fully characterises water molecule mobility in vivo, allowing an exploration of fibre tract integrity and orientation in the human brain. Using DTI this study demonstrates reduced fibre coherence (anisotropy) associated with cerebral infarction and in the corticospinal tract remote from the lesion, in five patients 2 to 6 months after ischaemic stroke. The study highlights the potential of DTI to detect and monitor the structural degeneration of fibre pathways, which may provide a better understanding of the pattern of clinical evolution after stroke.

Original language	English
Pages (from-to)	269-272
Number of pages	3
Journal	Journal of Neurology, Neurosurgery and Psychiatry
Volume	69
Issue number	2
DOIs	https://doi.org/10.1136/jnnp.69.2.269
Publication status	Published - Aug 2000

Keywords

Diffusion tensor
Magnetic resonance imaging
Pathophysiology
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/jnnp.69.2.269

Cite this

@article{41023edae69c460d92ddf653c5c382df,

title = "Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke",

abstract = "Diffusion tensor imaging (DTI) fully characterises water molecule mobility in vivo, allowing an exploration of fibre tract integrity and orientation in the human brain. Using DTI this study demonstrates reduced fibre coherence (anisotropy) associated with cerebral infarction and in the corticospinal tract remote from the lesion, in five patients 2 to 6 months after ischaemic stroke. The study highlights the potential of DTI to detect and monitor the structural degeneration of fibre pathways, which may provide a better understanding of the pattern of clinical evolution after stroke.",

keywords = "Diffusion tensor, Magnetic resonance imaging, Pathophysiology, Stroke",

author = "Werring, {David J.} and Toosy, {Ahmed T.} and Clark, {Christopher A.} and Parker, {Geoffrey J M} and Barker, {Gareth J.} and Miller, {David H.} and Thompson, {Alan J.}",

year = "2000",

month = aug,

doi = "10.1136/jnnp.69.2.269",

language = "English",

volume = "69",

pages = "269--272",

journal = "Journal of Neurology, Neurosurgery and Psychiatry",

issn = "0022-3050",

publisher = "BMJ ",

number = "2",

}

TY - JOUR

T1 - Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke

AU - Werring, David J.

AU - Toosy, Ahmed T.

AU - Clark, Christopher A.

AU - Parker, Geoffrey J M

AU - Barker, Gareth J.

AU - Miller, David H.

AU - Thompson, Alan J.

PY - 2000/8

Y1 - 2000/8

N2 - Diffusion tensor imaging (DTI) fully characterises water molecule mobility in vivo, allowing an exploration of fibre tract integrity and orientation in the human brain. Using DTI this study demonstrates reduced fibre coherence (anisotropy) associated with cerebral infarction and in the corticospinal tract remote from the lesion, in five patients 2 to 6 months after ischaemic stroke. The study highlights the potential of DTI to detect and monitor the structural degeneration of fibre pathways, which may provide a better understanding of the pattern of clinical evolution after stroke.

AB - Diffusion tensor imaging (DTI) fully characterises water molecule mobility in vivo, allowing an exploration of fibre tract integrity and orientation in the human brain. Using DTI this study demonstrates reduced fibre coherence (anisotropy) associated with cerebral infarction and in the corticospinal tract remote from the lesion, in five patients 2 to 6 months after ischaemic stroke. The study highlights the potential of DTI to detect and monitor the structural degeneration of fibre pathways, which may provide a better understanding of the pattern of clinical evolution after stroke.

KW - Diffusion tensor

KW - Magnetic resonance imaging

KW - Pathophysiology

KW - Stroke

U2 - 10.1136/jnnp.69.2.269

DO - 10.1136/jnnp.69.2.269

M3 - Article

SN - 0022-3050

VL - 69

SP - 269

EP - 272

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

IS - 2

ER -

Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this