Diffusion tensor MRI-based estimation of the influence of brain tissue anisotropy on the effects of transcranial magnetic stimulation

M. De Lucia, G. J M Parker, K. Embleton, J. M. Newton, V. Walsh

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We evaluate and discuss the relevance of fiber anisotropy in estimating the effect of transcranial magnetic stimulation (TMS) on the human brain. Finite element simulations were carried out on a three-dimensional model of the head that included anisotropic conductivity information derived from diffusion tensor imaging (DTI). The results show that anisotropy has minor effects both on the position of the main locus of activation and on its intensity. It has considerably more effect on the spatial distribution of the induced electric field, yielding differences of the order of 10% of the maximum induced field. Moreover the area affected by magnetic stimulation is slightly larger when we include fiber anisotropy in the calculations than in an isotropic model. We also show that the induced field observed in the anisotropic model does not always align with the local fiber orientation but rather follows specific patterns of parallelity. These findings will help to improve the estimation of the areas involved in magnetic stimulation. © 2007 Elsevier Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)1159-1170
    Number of pages11
    JournalNeuroImage
    Volume36
    Issue number4
    DOIs
    Publication statusPublished - 15 Jul 2007

    Keywords

    • Diffusion tensor imaging
    • Fiber orientation
    • Induced electromagnetic field
    • Three-dimensional head model
    • Transcranial magnetic stimulation

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