Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis

Collette S. Guy; Kathryn Murray; Matthew I. Gibson; Elizabeth Fullam

doi:10.1039/C9OB02222H

Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis

Collette S. Guy, Kathryn Murray, Matthew I. Gibson, Elizabeth Fullam

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Abstract

Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead to the evolution of resistance and bypass the need to cross the impermeable mycobacterial cell envelope barrier.
Graphical abstract: Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis

Original language	English
Pages (from-to)	9524-9528
Number of pages	5
Journal	Organic & biomolecular chemistry
Issue number	43
DOIs	https://doi.org/10.1039/C9OB02222H
Publication status	Published - 29 Oct 2019

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10.1039/C9OB02222H

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title = "Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis",

abstract = "Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead to the evolution of resistance and bypass the need to cross the impermeable mycobacterial cell envelope barrier.Graphical abstract: Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis",

author = "Guy, {Collette S.} and Kathryn Murray and Gibson, {Matthew I.} and Elizabeth Fullam",

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AU - Guy, Collette S.

AU - Murray, Kathryn

AU - Gibson, Matthew I.

AU - Fullam, Elizabeth

PY - 2019/10/29

Y1 - 2019/10/29

N2 - Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead to the evolution of resistance and bypass the need to cross the impermeable mycobacterial cell envelope barrier.Graphical abstract: Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis

AB - Dimeric benzoboroxoles that are covalently linked by a short scaffold enhance selective anti-tubercular activity. These multimeric benzoboroxole compounds are capable of engaging the specific extracellular Mycobacterium tuberculosis glycans, do not lead to the evolution of resistance and bypass the need to cross the impermeable mycobacterial cell envelope barrier.Graphical abstract: Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis

UR - https://doi.org/10.1039/C9OB02222H

U2 - 10.1039/C9OB02222H

DO - 10.1039/C9OB02222H

M3 - Article

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SP - 9524

EP - 9528

JO - Organic & biomolecular chemistry

JF - Organic & biomolecular chemistry

IS - 43

ER -

Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis

Abstract

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