Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

Aleksander M Grabiec; Nicholas Denny; John Doherty; Kaisa E Happonen; Jenny Hankinson; Emma Connolly; Mark E Fife; Toshifumi Fujimori; Naoya Fujino; Anupam Goenka; Susan Holden; Gael Gioan-Tavernier; Rajesh Shah; Peter Cook; Andrew MacDonald; Robert Niven; Björn Dahlbäck; Stephen Fowler; Angela Simpson; Tracy Hussell

doi:10.1016/j.jaci.2017.03.024

Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

Aleksander M Grabiec, Nicholas Denny, John Doherty, Kaisa E Happonen, Jenny Hankinson, Emma Connolly, Mark E Fife, Toshifumi Fujimori, Naoya Fujino, Anupam Goenka, Susan Holden, Gael Gioan-Tavernier, Rajesh Shah, Peter Cook, Andrew MacDonald, Robert Niven, Björn Dahlbäck, Stephen Fowler, Angela Simpson, Tracy Hussell

Research output: Contribution to journal › Letter › peer-review

Abstract

The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance

Original language	English
Pages (from-to)	1144-1146
Journal	Journal of Allergy and Clinical Immunology
Volume	140
Issue number	4
Early online date	12 Apr 2017
DOIs	https://doi.org/10.1016/j.jaci.2017.03.024
Publication status	Published - 12 Apr 2017

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Grabiec, A. M., Denny, N., Doherty, J., Happonen, K. E., Hankinson, J., Connolly, E., Fife, M. E., Fujimori, T., Fujino, N., Goenka, A., Holden, S., Gioan-Tavernier, G., Shah, R., Cook, P., MacDonald, A., Niven, R., Dahlbäck, B., Fowler, S., Simpson, A., & Hussell, T. (2017). Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma. Journal of Allergy and Clinical Immunology, 140(4), 1144-1146. https://doi.org/10.1016/j.jaci.2017.03.024

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title = "Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.",

abstract = "The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance",

author = "Grabiec, {Aleksander M} and Nicholas Denny and John Doherty and Happonen, {Kaisa E} and Jenny Hankinson and Emma Connolly and Fife, {Mark E} and Toshifumi Fujimori and Naoya Fujino and Anupam Goenka and Susan Holden and Gael Gioan-Tavernier and Rajesh Shah and Peter Cook and Andrew MacDonald and Robert Niven and Bj{\"o}rn Dahlb{\"a}ck and Stephen Fowler and Angela Simpson and Tracy Hussell",

year = "2017",

month = apr,

day = "12",

doi = "10.1016/j.jaci.2017.03.024",

language = "English",

volume = "140",

pages = "1144--1146",

journal = "Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

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Grabiec, AM, Denny, N, Doherty, J, Happonen, KE, Hankinson, J, Connolly, E, Fife, ME, Fujimori, T, Fujino, N, Goenka, A, Holden, S, Gioan-Tavernier, G, Shah, R, Cook, P , MacDonald, A, Niven, R, Dahlbäck, B, Fowler, S , Simpson, A & Hussell, T 2017, 'Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.', Journal of Allergy and Clinical Immunology, vol. 140, no. 4, pp. 1144-1146. https://doi.org/10.1016/j.jaci.2017.03.024

TY - JOUR

T1 - Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

AU - Grabiec, Aleksander M

AU - Denny, Nicholas

AU - Doherty, John

AU - Happonen, Kaisa E

AU - Hankinson, Jenny

AU - Connolly, Emma

AU - Fife, Mark E

AU - Fujimori, Toshifumi

AU - Fujino, Naoya

AU - Goenka, Anupam

AU - Holden, Susan

AU - Gioan-Tavernier, Gael

AU - Shah, Rajesh

AU - Cook, Peter

AU - MacDonald, Andrew

AU - Niven, Robert

AU - Dahlbäck, Björn

AU - Fowler, Stephen

AU - Simpson, Angela

AU - Hussell, Tracy

PY - 2017/4/12

Y1 - 2017/4/12

N2 - The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance

AB - The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance

U2 - 10.1016/j.jaci.2017.03.024

DO - 10.1016/j.jaci.2017.03.024

M3 - Letter

VL - 140

SP - 1144

EP - 1146

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 4

ER -

Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

Abstract

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