Dipole source localisation using independent component analysis: Single trial localisation of laser evoked pain

T. N. Hoang, W. El-Deredy, Deborah E. Bentley, Anthony K P Jones, Paulo J. Lisboa, Francis Mcglone

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The accuracy of the inverse solution that finds the spatial location of the generating sources from averaged scalp-recorded event related potentials (ERPs) relies on assumptions about the ERP signals and the sources. We provide evidence that using independent component analysis (ICA) as a signal decomposition filter prior to applying the inverse solution reveals sources that cannot be detected by conventional source localisation methods. Five clusters of sources emerged: a single source cluster in caudal cingulate and bilateral sources in secondary somatosensory cortex (SIT), inferior parietal cortex, premotor cortex and insular cortex. The locations of the source dipoles were consistent with findings using fMRI and PET but have not all been previously detected in a single electrophysiological study. In addition, the time-course of the activation of these dipoles was estimated. The results suggest that using ICA to localise single trial data is a powerful tool for exploring the spatio-temporal dynamics of rapid and complex brain processes.
    Original languageEnglish
    Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|Annu Int Conf IEEE Eng Med Biol Proc
    Pages403-406
    Number of pages3
    Volume26
    Publication statusPublished - 2004
    EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA
    Duration: 1 Jul 2004 → …

    Conference

    ConferenceConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
    CitySan Francisco, CA
    Period1/07/04 → …

    Keywords

    • Brain source localization
    • Event related potentials
    • Independent component analysis
    • Inverse solution
    • Laser evoked pain potentials

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