Direct arylation of thiazoles on water

Gemma L. Turner, James A. Morris, Michael F. Greaney

    Research output: Contribution to journalArticlepeer-review


    Wetter is better: The direct arylation of thiazoles on water is quicker, cleaner, and higher-yielding than arylation in organic solvents. The reaction works under mild conditions for an array of aryl iodides, producing 2,5-diaryl thiazoles in excellent yields. Importantly, novel bi-heteroaryl compounds are produced without the requirement for stoichiometric organometallic coupling agents. (Figure Presented). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)7996-8000
    Number of pages4
    JournalAngewandte Chemie - International Edition
    Issue number42
    Publication statusPublished - 2007


    • Direct arylation
    • Heterocycles
    • Homogeneous catalysis
    • Palladium
    • Water chemistry


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